TopoTarget A/S Symbion Fruebjergvej 3 2100 København Tel: +45 39 17 83 92 Fax: +45 39 17 94 92 CVR-nr: 25695771 www.topotarget.com To OMX, Investor news Investor News No. 3-07 / Copenhagen, 12 October 2007 TopoTarget Expands Investor and Public Relations Department Copenhagen, Denmark, 12 October 2007 - TopoTarget (OMX: TOPO) is pleased to announce that Rachel Curtis Gravesen has been appointed as Vice President International Investor and Public Relations (IR & PR) as part of the company's strategy to strengthen communication with the domestic market and to increase focus on communication with the international business community. “Rachel brings valuable experience and skills from the world of biotechnology business communication. TopoTarget is committed to high quality communication with the business and financial community and Rachel's appointment is an important part of our ongoing Investor and Public Relations strategy as we continue to build a business,” says Peter Buhl Jensen, CEO of TopoTarget. Previously, Rachel ran the IR & PR Department at Genmab A/S and most recently founded the IR & PR department at LifeCylePharma A/S. Rachel has broad experience working as a journalist and in financial communication, having worked at the BBC in the UK and as Nordic Editor at CNBC in Europe. Rachel has a BA and MA from the University of Cambridge and a Postgraduate qualification in Journalism from City University in London. Rachel will work together with Ulla Hald Buhl, Director of IR and Communications. TopoTarget A/S For further information, please contact: Dr. Peter Buhl Jensen Telephone +45 39 17 83 41 Chief Executive Officer Mobile +45 21 60 89 22 Rachel Curtis Gravesen Mobile +45 25 12 62 60 Vice President, International IR and PR Ulla Hald Buhl Mobile +45 21 70 10 49 Background information About TopoTarget TopoTarget (OMX: TOPO) is a biotech company, headquartered in Denmark and with subsidiaries in US, Switzerland, Germany and the UK, dedicated to finding ''Answers for cancer'' and developing improved cancer therapies. TopoTarget is founded and run by clinical cancer specialists and combines years of hands-on clinical experience with in-depth understanding of the molecular mechanisms of cancer. Focus lies on highly predictive cancer models and key cancer targets (including HDACi, NAD+, mTOR, FASligand and topoisomerase II inhibitors) and a strong development foundation has been built. TopoTarget has a broad portfolio of small molecule pre-clinical drug candidates and eight drugs (both small molecules and protein based) are in clinical development, including both novel anti-cancer therapeutics and new cancer indications for existing drugs. Savene™/Totect™ was approved by EMEA in 2006 and the FDA in 2007 and is TopoTarget's first product on the market. For more information, please refer to www.topotarget.com. TopoTarget Safe Harbour Statement This announcement may contain forward-looking statements, including statements about our expectations of the progression of our preclinical and clinical pipeline including the timing for commencement and completion of clinical trials and with respect to cash burn guidance. Such statements are based on management's current expectations and are subject to a number of risks and uncertainties that could cause actual results to differ materially from those described in the forward-looking statements. TopoTarget cautions investors that there can be no assurance that actual results or business conditions will not differ materially from those projected or suggested in such forward-looking statements as a result of various factors, including, but not limited to, the following: The risk that any one or more of the drug development programs of TopoTarget will not proceed as planned for technical, scientific or commercial reasons or due to patient enrolment issues or based on new information from non-clinical or clinical studies or from other sources; the success of competing products and technologies; technological uncertainty and product development risks; uncertainty of additional funding; TopoTarget's history of incurring losses and the uncertainty of achieving profitability; TopoTarget's stage of development as a biopharmaceutical company; government regulation; patent infringement claims against TopoTarget's products, processes and technologies; the ability to protect TopoTarget's patents and proprietary rights; uncertainties relating to commercialization rights; and product liability expo-sure; We disclaim any intention or obligation to update or revise any forward-looking statements, whether as a result of new information, future events, or otherwise, unless required by law.