Express Scripts Reports a 35 Percent Increase in First Quarter Earnings Per Share

2008 Earnings Per Share and Cash Flow Guidance Increased


ST. LOUIS, April 29, 2008 (PRIME NEWSWIRE) -- Express Scripts, Inc. (Nasdaq:ESRX) announced first quarter net income from continuing operations of $178.3 million, or $0.70 per diluted share representing a 35% increase over $0.52 on an adjusted basis for the same quarter last year.

The Company reported record first quarter cash flow from continuing operations of $248.3 million compared to $158.9 million for the same period last year. During the quarter, Express Scripts repurchased 2.0 million shares of common stock for $121.1 million, leaving 11.2 million shares available under its current share repurchase program.

"Earlier this month, we launched the Center for Cost-Effective Consumerism with a blue ribbon advisory board representing the nation's leading experts in the science of human behavior and decision making," stated George Paz, president, chief executive officer and chairman. "In partnership with this panel, we will develop and deploy proven tools to bring about positive behavior change at the level of the individual consumer.

"This focus will result in improved health outcomes and lower costs for our clients and their patients by increasing the use of generics, home delivery, and lower-cost preferred brands. This will further differentiate Express Scripts in the marketplace, keep us true to our commitment of alignment of interests with our clients, and generate superior performance for our stockholders."

Q1 2008 Financial Highlights (comparative data for 2007 is reflected on an adjusted basis -- see Tables 2 and 3 below)



 * The Company's industry-leading generic utilization rate increased
   to 65.1% from 60.3% last year.
 * Consolidated gross profit increased 14% to $468.7 million from
   $411.3 million in the first quarter of 2007.
 * EBITDA increased 19% to $319.1 million from $268.9 million last
   year and EBITDA per adjusted claim increased 17% to $2.46 from
   $2.10 last year.
 * Net income from continuing operations increased 26% to
   $178.3 million from $141.8 million in the first quarter of 2007.
   o Specialty and Ancillary Services ("SAAS") incurred charges
     of $6.0 million for bad debt expense and other costs incurred
     in the specialty distribution business.
   o This charge was partially offset by a $2.6 million benefit
     from the favorable settlement of prior year tax items.

2008 Guidance

The Company now believes its 2008 earnings per diluted share from continuing operations will be in a range of $2.95 to $3.03. Cash flow from operations is expected to be in a range of $900 million to $1 billion.

About Express Scripts

Express Scripts, Inc. is one of the largest PBM companies in North America, providing PBM services to thousands of client groups, including managed-care organizations, insurance carriers, employers, third-party administrators, public sector, workers compensation, and union-sponsored benefit plans.

Express Scripts provides integrated PBM services, including network-pharmacy claims processing, home delivery services, benefit-design consultation, drug-utilization review, formulary management, and medical- and drug-data analysis services. The Company also distributes a full range of biopharmaceutical products directly to patients or their physicians, and provides extensive cost-management and patient-care services.

Express Scripts is headquartered in St. Louis, Missouri. More information can be found at http://www.express-scripts.com, which includes expanded investor information and resources. More information on the Center for Cost-Effective Consumerism can be found at http://www.consumerology.org.

SAFE HARBOR STATEMENT

This press release contains forward-looking statements, including, but not limited to, statements related to the Company's plans, objectives, expectations (financial and otherwise) or intentions. Actual results may differ significantly from those projected or suggested in any forward-looking statements. Factors that may impact these forward-looking statements can be found in the Management's Discussion and Analysis of Financial Condition and Results of Operations in our Form 10-Q on file with the SEC. A copy of this form can be found at the investor relations section of Express Scripts web site at http://www.express-scripts.com

We do not undertake any obligation to release publicly any revisions to such forward-looking statements to reflect events or circumstances after the date hereof or to reflect the occurrence of unanticipated events.



                         EXPRESS SCRIPTS, INC.
            Unaudited Consolidated Statement of Operations

                                                   Three months ended
                                                        March 31,
                                                  --------------------
   (in millions, except per share data)             2008        2007
                                                  --------    --------

 Revenues(1)                                      $4,604.2    $4,508.9
 Cost of revenues(1)                               4,135.5     4,088.6
                                                  --------    --------
   Gross profit                                      468.7       420.3
 Selling, general and administrative                 174.1       168.0
                                                  --------    --------
 Operating income                                    294.6       252.3
                                                  --------    --------
 Other (expense) income:
   Non-operating charges, net                           --       (23.0)
   Undistributed loss from joint venture              (0.2)       (0.4)
   Interest income                                     5.3         2.8
   Interest expense                                  (23.3)      (22.2)
                                                  --------    --------
                                                     (18.2)      (42.8)
                                                  --------    --------
 Income before income taxes                          276.4       209.5
 Provision for income taxes                           98.1        76.6
                                                  --------    --------
 Net income from continuing operations               178.3       132.9
 Net (loss) income from discontinued operations,
  net of tax                                          (1.1)        0.8
                                                  --------    --------
 Net income                                       $  177.2    $  133.7
                                                  ========    ========

 Weighted average number of common shares
 outstanding during the period
   Basic:                                            252.3       271.6
   Diluted:                                          255.7       275.4


 Basic earnings per share
     Continuing operations                        $   0.71    $   0.49
     Discontinued operations                          0.00        0.00
     Net earnings                                     0.70        0.49


 Diluted earnings per share
     Continuing operations                        $   0.70    $   0.48
     Discontinued operations                          0.00        0.00
     Net earnings                                     0.69        0.49


 (1) Excludes estimated retail pharmacy co-payments of $945.1 and
     $988.2 for the three months ended March 31, 2008 and 2007,
     respectively. These are amounts we instructed retail pharmacies
     to collect from members. We have no information regarding actual
     co-payments collected.


                         EXPRESS SCRIPTS, INC.
                 Unaudited Consolidated Balance Sheet

                                                  March 31,   Dec. 31,
 (in millions, except share data)                   2008        2007
                                                  --------    --------
 Assets
 Current assets:
   Cash and cash equivalents                      $  511.9    $  434.7
   Restricted cash and investments                     3.2         2.2
   Receivables, net                                1,222.1     1,184.6
   Inventories                                       166.5       166.1
   Deferred taxes                                    121.3       121.1
   Prepaid expenses and other current assets          17.0        18.7
   Current assets of discontinued operations          32.7        40.4
                                                  --------    --------
     Total current assets                          2,074.7     1,967.8
 Property and equipment, net                         210.1       215.5
 Goodwill                                          2,694.2     2,695.3
 Other intangible assets, net                        332.5       342.0
 Other assets                                         28.4        30.2
 Non-current assets of discontinued operations         7.6         5.6
                                                  --------    --------
     Total assets                                 $5,347.5    $5,256.4
                                                  ========    ========

 Liabilities and Stockholders' Equity
 Current liabilities:
   Claims and rebates payable                     $1,286.9    $1,258.9
   Accounts payable                                  532.0       517.3
   Accrued expenses                                  459.4       432.5
   Current maturities of long-term debt              280.1       260.1
   Current liabilities of discontinued operations      6.4         6.2
                                                  --------    --------
     Total current liabilities                     2,564.8     2,475.0
 Long-term debt                                    1,680.3     1,760.3
 Other liabilities                                   325.2       324.7
                                                  --------    --------
     Total liabilities                             4,570.3     4,560.0
                                                  --------    --------

 Stockholders' Equity:
   Preferred stock, 5,000,000 shares authorized,
    $0.01 par value per share; and no shares
    issued and outstanding                              --          --
   Common stock, 650,000,000 shares authorized,
    $0.01 par value per share; shares issued:
    318,892,000 and 318,886,000, respectively;
    shares outstanding: 251,145,000 and
    252,371,000, respectively                          3.2         3.2
   Additional paid-in capital                        581.4       564.5
   Accumulated other comprehensive income             17.8        20.9
   Retained earnings                               2,762.1     2,584.9
                                                  --------    --------
                                                   3,364.5     3,173.5
   Common stock in treasury at cost, 67,747,000
    and 66,515,000 shares, respectively           (2,587.3)   (2,477.1)
                                                  --------    --------
     Total stockholders' equity                      777.2       696.4
                                                  --------    --------
     Total liabilities and stockholders' equity   $5,347.5    $5,256.4
                                                  ========    ========


                         EXPRESS SCRIPTS, INC.
       Unaudited Condensed Consolidated Statement of Cash Flows

                                                   Three months ended
                                                        March 31,
                                                  --------------------
 (in millions)                                      2008        2007
                                                  --------    --------

 Cash flow from operating activities:
 Net income                                       $  177.2    $  133.7
 Net loss (income) from discontinued operations,
  net of tax                                           1.1        (0.8)
                                                  --------    --------
   Net income from continuing operations             178.3       132.9
 Adjustments to reconcile net income to net
  cash provided by operating activities:
   Depreciation and amortization                      24.5        25.6
   Non-cash adjustments to net income                 21.3         3.4
   Change in operating assets and liabilities:
     Claims and rebates payable                       28.0       (36.8)
     Other net changes in operating assets and
      liabilities                                     (3.8)       33.8
                                                  --------    --------
 Net cash provided by operating activities --
  continuing operations                              248.3       158.9
 Net cash provided by (used in) operating
  activities -- discontinued operations                4.7        (3.3)
                                                  --------    --------
 Net cash flows from operating activities            253.0       155.6
                                                  --------    --------

 Cash flows from investing activities:
   Purchases of property and equipment               (11.7)       (8.3)
   Other                                              (0.4)       (0.4)
                                                  --------    --------
 Net cash used in investing activities --
  continuing operations                              (12.1)       (8.7)
 Net cash used in investing activities --
  discontinued operations                               --        (0.4)
                                                  --------    --------
 Net cash used in investing activities               (12.1)       (9.1)
                                                  --------    --------

 Cash flows from financing activities:
   Repayment of long-term debt                       (60.0)      (40.0)
   Repayment of revolving credit line, net              --       (50.0)
   Tax benefit relating to employee stock
    compensation                                      12.0         6.7
   Treasury stock acquired                          (121.1)         --
   Net proceeds from employee stock plans              6.7        13.0
                                                  --------    --------
 Net cash used in financing activities              (162.4)      (70.3)
                                                  --------    --------

 Effect of foreign currency translation
  adjustment                                          (1.3)         --
                                                  --------    --------

 Net increase in cash and cash equivalents            77.2        76.2
 Cash and cash equivalents at beginning of period    434.7       131.0
                                                  --------    --------
 Cash and cash equivalents at end of period       $  511.9    $  207.2
                                                  ========    ========


                         EXPRESS SCRIPTS, INC.
          (In millions, except per claim and per share data)

                                Table 1
                    Unaudited Operating Statistics

                      3 months  3 months  3 months  3 months  3 months
                       ended     ended     ended     ended     ended
                     3/31/2008 12/31/2007 9/30/2007 6/30/2007 3/31/2007
                     --------- ---------- --------- --------- ---------
 Revenues
 --------
 PBM                   3,670.8   3,762.4   3,612.4   3,669.3   3,608.9
 SAAS                    933.4     931.6     882.6     906.4     900.0
                      ------------------------------------------------
   Total
    consolidated
    revenues           4,604.2   4,694.0   4,495.0   4,575.7   4,508.9
                      ================================================

 Claims Detail
 -------------
 Network(1)               98.2      96.9      92.1      94.1      96.8
 Home delivery            10.1      10.3      10.2      10.2      10.0
                      --------  --------  --------  --------  --------
   Total PBM claims      108.3     107.2     102.3     104.3     106.8
                      --------  --------  --------  --------  --------
   Adjusted PBM
    claims(2)            128.5     127.8     122.7     124.8     126.8
                      ========  ========  ========  ========  ========
 SAAS claims(3)            1.1       1.2       1.2       1.2       1.2
                      --------  --------  --------  --------  --------
   Total adjusted
    claims(4)            129.6     129.0     123.9     126.0     128.0
                      ========  ========  ========  ========  ========

 Per Adjusted Claim
 ------------------
 Adjusted EBITDA(5)   $   2.46  $   2.49  $   2.48  $   2.30  $   2.10


              2007 Calculation of Adjusted Gross Profit,
                     Operating Income and EBITDA
                                Table 2

                                         3 Months Ended March 31, 2007
                                         -----------------------------
                                            PBM       SAAS      Total
                                          --------  --------  --------

 Gross Profit, as reported                $  368.3  $   52.0  $  420.3
 Non-recurring benefit-settlement of
  contractual item with supply chain
  vendor                                      (9.0)       --      (9.0)
                                          ----------------------------
 Adjusted Gross Profit                    $  359.3  $   52.0  $  411.3
                                          ============================

 Operating Income, as reported            $  237.0  $   15.3  $  252.3
 Non-recurring benefit-settlement of
  contractual item with supply chain 
  vendor                                      (9.0)       --      (9.0)
                                          ----------------------------
 Adjusted Operating Income                $  228.0  $   15.3  $  243.3
                                          ============================

 EBITDA, as reported(5)                                       $  277.9
 Non-recurring benefit-settlement of
  contractual item with supply chain vendor                       (9.0)
                                                              --------
 Adjusted EBITDA                                              $  268.9
                                                              ========


 The Company is providing adjusted gross profit, operating income and
 EBITDA excluding the impact of non-recurring items in order to
 compare the underlying financial performance to prior periods

     2007 Unaudited Earnings From Continuing Operations Excluding
                         Non-recurring Items
                                Table 3

                                                 3 Months Ended
                                                 March 31, 2007
                                                 --------------

 Reported income before taxes                       $  209.5

   Non-recurring benefit-settlement of contractual
    item with supply chain vendor                       (9.0)
   Transaction costs for terminated proposal to
    acquire Caremark, less special dividend
    received on Caremark                                23.0
                                                    --------
 Income before tax excluding non-recurring items       223.5

 Provision for income taxes                             81.7
                                                    --------

 Adjusted net income from continuing operations     $  141.8
                                                    ========

 Weighted average number of share outstanding
  during the period - diluted                          275.4
                                                    ========

 Diluted earnings per share excluding
  non-recurring items                               $   0.52

 Diluted earnings per share from continuing
  operations as reported                            $   0.48
                                                    --------

 Impact of non-recurring items                      $  (0.04)
                                                    ========

 The Company is providing diluted earnings per share excluding the
 impact of certain charges in order to compare the underlying financial
 performance to prior periods.


                         EXPRESS SCRIPTS, INC.

                Notes to Unaudited Operating Statistics
                             (in millions)

 (1) Network claims exclude drug formulary only claims where we only
     administer the clients formulary and approximately 0.5 million
     manual claims per quarter.

 (2) PBM adjusted claims represent network claims plus mail claims,
     which are multiplied by 3, as mail claims are typically 90 day
     claims and network claims are generally 30 day claims. Adjusted
     claims calculated from the table may differ due to rounding.

 (3) Specialty and Ancillary Services (SAAS) claims represent the
     distribution of pharmaceuticals through Patient Assistance
     Programs and the distribution of pharmaceuticals where we have
     been selected by the pharmaceutical manufacturer as part of a
     limited distribution network. They also represent the
     distribution of specialty drugs through our CuraScript subsidiary.

 (4) Total adjusted claims includes PBM adjusted claims plus SAAS
     claims.

 (5) The following is a reconciliation of EBITDA from continuing
     operations to net income from continuing operations and to net
     cash provided by operating activities from continuing operations
     as the Company believes they are the most directly comparable
     measures calculated under Generally Accepted Accounting
     Principles:

                                                      3 months ended
                                                         March 31,
                                                    ------------------
                                                      2008      2007
                                                    --------  --------
 Net income from continuing operations              $  178.3  $  132.9
   Income taxes                                         98.1      76.6
   Depreciation and amortization*                       24.5      25.6
   Interest expense, net                                18.0      19.4
   Undistributed loss from joint venture                 0.2       0.4
   Non-operating charges, net                             --      23.0
                                                    --------  --------
 EBITDA from continuing operations                     319.1     277.9
   Current income taxes                                (96.0)    (84.6)
   Interest expense less amortization                  (17.4)    (18.9)
   Undistributed loss from joint venture                (0.2)     (0.4)
   Non-operating charges, net                             --     (23.0)
   Other adjustments to reconcile net income                     
    to net cash provided by operating activities        42.8       7.9
                                                    ------------------
 Net cash provided by operating activities from
  continuing operations                             $  248.3  $  158.9
                                                    ========  ========

 EBITDA is earnings before other income (expense), interest, taxes,
 depreciation and amortization, or operating income plus depreciation
 and amortization. EBITDA is presented because it is a widely accepted
 indicator of a company's ability to service indebtedness and is
 frequently used to evaluate a company's performance. EBITDA, however,
 should not be considered as an alternative to net income, as a measure
 of operating performance, as an alternative to cash flow, as a measure
 of liquidity or as a substitute for any other measure computed in
 accordance with accounting principles generally accepted in the United
 States. In addition, our definition and calculation of EBITDA may not
 be comparable to that used by other companies.

 * Includes depreciation and amortization expense of:
         Gross profit                                    7.0       9.0
         Selling, general and administrative            17.5      16.6
                                                    --------  --------
                                                        24.5      25.6
                                                    ========  ========


            

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