TopoTarget A/S Symbion Fruebjergvej 3 DK 2100 Copenhagen Denmark Tel: +45 39 17 83 92 Fax: +45 39 17 94 92 CVR-nr: 25695771 www.topotarget.com Following the company's successful rights issue of shares completed in the beginning of July 2009, the board of directors of TopoTarget A/S has decided to propose a change in the composition of the board of directors as described in further detail below and therefore convenes an Extraordinary General Meeting in TopoTarget A/S. The extraordinary general meeting will be held on Thursday 23 July 2009 at 4.00 PM. at the company's address: Symbion Fruebjergvej 3 DK-2100 Copenhagen Ø Denmark The agenda for the Extraordinary General Meeting is as follows: 1. Election of Board members. 2. Authority to the chairman of the general meeting. 3. Miscellaneous. Re. 1 The present board members Jesper Zeuthen and Torbjörn Bjerke have notified the company that they will resign as board members in connection with the extraordinary general meeting. A proposal is made that Anders Fink Vadsholt, Per Samuelsson and Bo Jesper Hansen are elected as new members of the company's board of directors, all for a period until the company's annual general meeting to be held in 2010. If Anders Fink Vadsholt, Per Samuelsson and Bo Jesper Hansen are elected as board members at the general meeting, the board of directors of TopoTarget A/S will consist of the following seven members: Håkan Åström, Jeffrey H. Buchalter, Anders Gersel Pedersen, Ingelise Saunders, Anders Fink Vadsholt, Per Samuelsson and Bo Jesper Hansen. About Anders Fink Vadsholt: Anders Fink Vadsholt is a partner at BankInvest Biomedical Venture (BBV), which he joined in 2005. Mr. Vadsholt manages a number of BBV investments and currently serves on the board of Zealand Pharma A/S. Mr. Vadsholt has 12 years of biotech experience from investment banking, venture capital and start-up companies. He is a co-founder of a number of Biotech & IT companies, including 7TM Pharma A/S, where he was also Chief Financial Officer. He gained his investment banking experience at Carnegie Bank working within corporate finance and life science security analysis. Mr. Vadsholt has an MBA from Melbourne University, a master's degree in Business Law and Finance from Copenhagen Business School. About Per Samuelsson: Per Samuelsson is a Partner with HealthCap, a venture capital fund and he is based in Stockholm, Sweden. Prior to joining Odlander Fredrikson / HealthCap in the year 2000, Mr. Samuelsson gained over 15 years of investment banking experience, mainly with Aros Securities in Sweden. In his most recent position with Aros Securities, as a Director in the firm's corporate finance department, he specialised in the areas of Merger Transactions, Initial Public Offerings and Equity Incentive Programs. Prior to this Mr. Samuelsson was head of Research, also at Aros Securities. Mr. Samuelsson received his M.Sc. in Engineering from the Institute of Technology in Linköping. Mr. Samuelsson currently holds positions in the following companies: Algeta ASA (board member), BioStratum Inc. (board member), Cardoz AB (board member), Millicore AB (board member), Nucleonics Inc. (board member) and Optivy AB (board member). About Bo Jesper Hansen: Since 1998 the CEO & President of Swedish Orphan International Group of Companies consisting of the subsidiaries in Sweden, Denmark, Finland, Norway, the Baltic States, the UK, Germany, France, Spain, Italy and Japan. Mr. Hansen has been in Swedish Orphan International AB since 1993 having established the subsidiaries in Norway and Denmark and is also responsible for the current expansion into the big five countries in Europe. Has held several positions within the company before becoming Vice President for the parent company and later on being appointed the company CEO. During this period he has also co-founded the Shared Clinic “The Prostate Clinic” in Denmark. Mr. Hansen experience includes International Marketing and Contract negotiations, extensive knowledge within Regulatory, Pharmacovigilance, Medical Marketing and Business Development and he has close collaborations with persons involved in the Pharmaceutical Industry in general and in the Orphan Drug area in particular. Prior to joining Swedish Orphan International AB, Mr. Hansen worked as a medical advisor for several of the biggest Pharmaceutical Companies through the privately owned and founded company Scandinavian Medical Research. Today, Mr. Hansen acts as ordinary member of the board in the Swedish Orphan International Group, Vivolution A/S, and Zymentec A/S. Dr. Hansen is a Medical doctor, PhD from the University of Copenhagen having significant research experience. Dr. Hansen is the author of more than 40 publications in international peer-review scientific journals and is an experienced presenter at international scientific congresses. Re. 2 The Board of Directors proposes that the chairman of the meeting or a substitute duly appointed by him be authorised to apply for registration of the resolutions passed and to make any such amendments thereto as may be required by the Danish Commerce and Companies Agency as a condition for registration or approval. Adoption of the proposals comprised by no. 1 and 2 of the agenda are made by a simple majority of the votes cast. The company's nominal share capital currently amounts to DKK 132,609,020 consisting of 132,609,020 shares of DKK 1 nominal value. At General Meetings, each share amount of DKK 1 nominal value carries one vote. The shareholders exercise their financial rights through their own deposit banks. The agenda with the complete proposed resolutions will be available for inspection at the company's offices c/o Symbion, Fruebjergvej 3, DK-2100 Copenhagen Ø no later than eight days before the General Meeting and will be forwarded to all registered shareholders who have requested the same not later than eight days before the General Meeting. Admission card: Any shareholder is entitled to attend the general meeting after having submitted a request for an admission card no later than Monday, 20 July 2009 at 4:00 PM. Admission cards are issued to shareholders registered in the company's Shareholder Register or against presentation of a deposit transcript from VP Securities Services or the account-holding bank. The transcript must not be dated more than eight days before the date of presentation. Admission cards and voting papers may be requested at the company's website: www.topotarget.com. In order to do so, shareholders will need to type in their VP-account number. Shareholders can obtain their VP-account number from their own depository bank. Admission cards and voting papers may also obtained through the company's offices on all weekdays (Saturdays excepted) in accordance with Article 12 of the Articles of Association either in person or by telephone at +45 39 17 83 92. Shareholders who are unable to be present at the General Meeting may issue a proxy to the Board of Directors or to a person appointed by such shareholder attending the General Meeting. TopoTarget A/S For further information, please contact: Peter Buhl Jensen Telephone +45 39 17 94 99 CEO Mobile +45 21 60 89 22 Background information About TopoTarget TopoTarget (OMX: TOPO) is an international biotech company headquartered in Denmark, dedicated to finding ''Answers for Cancer'' and developing improved cancer therapies. The company was founded and is run by clinical cancer specialists and combines years of hands-on clinical experience with in-depth understanding of the molecular mechanisms of cancer. TopoTarget has a broad clinical pipeline but is currently focusing on the development of belinostat, which has shown proof of concept as monotherapy in treating haematological malignancies and positive results in solid tumours where it can be used in combination with full doses of chemotherapy, and is in phase III in PTCL. TopoTarget's expertise in translational research is utilizing its highly predictive in vivo and in vitro cancer models. TopoTarget is directing its efforts on key cancer targets including HDACi, NAD+, mTOR, FasLigand and topoisomerase II inhibitors. The company's first marketed product Savene®/Totect® was approved by EMEA in 2006 and the FDA in 2007 and is marketed by TopoTarget's own sales force in Europe and the US. For more information, please refer to www.topotarget.com.