Director/PDMR Shareholding

Transaction by Persons Discharging Managerial Responsibilities

Disclosure Rule DTR 3.1.4

The following individuals, who are all Directors of the Company, have notified
us that they have purchased AstraZeneca PLC Ordinary Shares of $0.25 each or
AstraZeneca American Depositary Shares (ADSs).

One AstraZeneca ADS equals one AstraZeneca PLC Ordinary Share of $0.25.

Name of     Date of       Date of   Number of  Purchase price
Director    notification  purchase  shares
                                    purchased
Cori        1 May 2015    29 April  700        $69.21
Bargmann                  2015
Ann Cairns  1 May 2015    30 April  1,100      4455p
                          2015
Jean        29 April      28 April  2,500      4536p
-Philippe   2015          2015
Courtois

A C N Kemp

Company Secretary

1 May 2015