La Chaux-de-Fonds, Switzerland, March 26, 2019 (GLOBE NEWSWIRE) -- Rhizen Pharmaceuticals S.A. announces poster presentation of RP4010, a novel first-in-class CRAC channel inhibitor in preclinical models of Gastrointestinal (GI) cancers.
Highlights from the poster include:
- Treatment of GI cancer cell lines with single-agent RP4010 decreased cell growth
- RP4010 synergized with gemcitabine and nab-paclitaxel in Pancreatic Ductal Adenocarcinoma (PDAC)
- RP4010 synergized with nab-paclitaxel in Gastric Cancer (GC)
- RP4010 significantly enhanced the activity of everolimus in Pancreatic Neuroendocrine Tumors (PNETs)
About RP4010:
RP4010 is a novel first-in-class oral small molecule inhibitor of calcium release activated calcium (CRAC) channel pathway with demonstrated preclinical activity in a broad range of cancers. Blockade of store-operated calcium entry (SOCE) through CRAC channel inhibition could suppress tumor growth via a number of downstream events including inhibition of NFAT dephosphorylation as well as calcium-dependent activation of Akt/NF-kB and ERK 1/2 pathways. A multi-center Phase I/IB dose-escalation trial evaluating the safety and efficacy of RP4010, a CRAC channel inhibitor in patients with relapsed or refractory Lymphomas is currently ongoing in USA and Australia (ClinicalTrials.gov Identifier: NCT03119467).
Details of the poster presentation:
-- Poster Title: Efficacy of RP4010, a calcium release-activated calcium (CRAC) channel inhibitor, in preclinical models of gastrointestinal cancers
- Session Category: Experimental and Molecular Therapeutics
- Session Title: Novel Antitumor Agents 1
- Session Date & Time: Tuesday, April 2, 2019; 8:00 AM – 12:00 PM
- Location: Georgia World Congress Center, Exhibit Hall B, Poster Section 14
- Poster Board Number: 3
- Permanent Abstract No.: 3069
About Rhizen Pharmaceuticals S.A.:
Rhizen Pharmaceuticals is an innovative, clinical-stage biopharmaceutical company focused on the discovery and development of novel therapeutics for the treatment of cancer, immune and metabolic disorders. Since its establishment in 2008, Rhizen has created a diverse pipeline of proprietary drug candidates targeting several cancers and immune associated cellular pathways. Rhizen is headquartered in La-Chaux-de-Fonds, Switzerland. For additional information, please visit Rhizen’s website, www.rhizen.com.