Summit’s Pipeline Expands with Series of New Mechanism Antibiotics Targeting Enterobacteriaceae

Summit Therapeutics plc 
(‘Summit’ or the ’Company’)

Summit’s Pipeline Expands with Series of New Mechanism Antibiotics Targeting Enterobacteriaceae  

• Data to be Presented in Oral Session at ECCMID 2019

Oxford, UK, and Cambridge, MA, US, 3 April 2019 – Summit Therapeutics plc (NASDAQ: SMMT, AIM: SUMM), a leader in new mechanism antibiotic innovation, today announces the expansion of its pipeline with a series of new mechanism antibiotics, DDS-04, which targets Enterobacteriaceae. Key data from this series will be presented in an oral session at the 29^th European Congress of Clinical Microbiology & Infectious Diseases (‘ECCMID’), taking place 13-16 April 2019 in Amsterdam.

“The DDS-04 series provides us with a major opportunity to improve patient outcomes across several body sites where Enterobacteriaceae cause infection,” said Dr David Roblin, President of R&D of Summit. “We look forward to developing the programme to show compelling clinical and economic data that offer significant advantages over standard of care for the patients in need.”

Summit’s DDS-04 series of new mechanism antibiotic compounds acts specifically on Enterobacteriaceae via LolCDE, an unexploited bacterial target. It is the first project to emerge from the Company’s ESKAPE pathogen programme. Enterobacteriaceae are a family of Gram-negative bacteria, which include the critical threats Klebsiella pneumoniae and Escherichia coli. These bacteria are responsible for a large number of severe and often deadly infections of the bloodstream, lungs and urinary tract. The DDS-04 series has shown activity across a global panel of K. pneumoniae and E. coli strains, including strains resistant to current standard of care treatments.

Details of the presentation are as follows:

Date: 14 April 2019
Time: 1:42pm CEST
Session: Novel antimicrobial agents and discovery strategies
Location: Hall M
Title: Novel Small-Molecule Inhibitors of Bacterial Lipoprotein Transport with Potent Antimicrobial Activity against Enterobacteriaceae
Authors: E. Breidenstein, O. Abdulle, T. Avis, C. Charrier, C. Ciardullo, C. Coward, T. Duffy, N. Khan, C. Mason, P. Meo and D. Powell

About Enterobacteriaceae
Enterobacteriaceae are a family of Gram-negative bacteria responsible for a large number of severe and often deadly infections of the bloodstream, lungs and urinary tract. Increasing resistance of Enterobacteriaceae has rendered many marketed antibiotics ineffective against these bacteria. Two of the most alarming antibiotic resistance trends are extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae and carbapenem-resistant Enterobacteriaceae (CRE). ESBL is an enzyme that allows bacteria to become resistant to a wide variety of penicillin and cephalosporin antibiotics. ESBL-producing Enterobacteriaceae account for an estimated 26,000 infections annually in the US with 1,700 deaths, according to the US Centers for Drug Control and Prevention (‘CDC’). CRE are resistant to nearly all existing antibiotics, including carbapenems which are considered the antibiotics of last resort. CRE account for an estimated 9,000 infections per year in the US and 600 deaths, according to the CDC.

About Summit Therapeutics
Summit Therapeutics is a leader in antibiotic innovation. Our new mechanism antibiotics are designed to become the new standards of care for the benefit of patients and create value for payors and healthcare providers. We are currently developing new mechanism antibiotics for infections caused by C. difficile, N. gonorrhoeae and ESKAPE pathogens. We are using our proprietary Discuva Platform to expand our pipeline. For more information, visit www.summitplc.com and follow us on Twitter @summitplc.

This announcement contains inside information for the purposes of Article 7 of EU Regulation 596/2014 (MAR).

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