Global Oligonucleotide Synthesis Market Analysis and Opportunity Forecast 2023-2028 - RNA-based Therapeutics Show Promise, Boosting Demand for Tailored Oligonucleotides

Dublin, Jan. 10, 2024 (GLOBE NEWSWIRE) -- The "Global Oligonucleotide Synthesis Market - Industry Size, Share, Trends, Opportunity, and Forecast, 2018-2028" report has been added to's offering.

The Global Oligonucleotide Synthesis Market, valued at USD 4.03 billion in 2022, is anticipated to experience robust growth in the forecast period, with an expected Compound Annual Growth Rate (CAGR) of 13.3% through 2028.

This market holds a significant position in the biotechnology and pharmaceutical industries, serving as a vital intersection for cutting-edge research and therapeutic development. The remarkable expansion in recent years is driven by the increasing demand for custom-designed oligonucleotides across diverse applications, including gene editing, molecular diagnostics, and drug discovery.

Genomics, personalized medicine, and RNA-based therapeutics contribute to this surge, relying heavily on precise oligonucleotide synthesis. The market's competitive landscape features established leaders and innovative startups, with technological advancements enhancing production efficiency. Regulatory approvals and industry standards play a crucial role in ensuring quality and safety.

Key Market Drivers:

  1. RNA-based Therapeutics:
    • RNA-based therapeutics, including mRNA vaccines and gene therapies, heavily rely on precise oligonucleotide synthesis.
    • The success of mRNA vaccines has led to increased demand for custom oligonucleotides, driving market growth.
    • RNA-based therapeutics show promise in treating genetic disorders, cancers, and rare diseases, further boosting demand for tailored oligonucleotides.
  2. Advancements in Genomic Research:
    • Next-Generation Sequencing (NGS) and CRISPR-Cas9 gene editing have fueled genomic research, increasing the demand for custom-designed oligonucleotides.
    • Oligonucleotides are essential for whole-genome sequencing, gene expression profiling, and functional genomics, supporting researchers in decoding genetic material.

Key Market Challenges:

  1. Efficiency and Scalability:
    • Meeting the escalating demand for custom oligonucleotides poses challenges in terms of efficiency and scalability.
    • Balancing fast, precise, and error-free synthesis processes with the need for scalability is crucial.
    • The synthesis of long or highly modified oligonucleotides may require specialized equipment, impacting efficiency.
  2. Cost Constraints:
    • Cost constraints affect both research and commercial applications of oligonucleotides.
    • High expenses associated with the synthesis of long or chemically modified sequences can be prohibitive.
    • Maintaining competitive pricing while ensuring quality and customization remains challenging for companies.

Key Market Trends:

  1. Therapeutic Advancements:
    • RNA-based therapeutics, including mRNA vaccines and gene therapies, drive a new era in precision medicine.
    • Oligonucleotide synthesis enables the production of synthetic RNA molecules critical for therapeutic efficacy.
    • The market contributes to transformative advancements in healthcare, emphasizing the importance of staying technologically advanced.
  2. Gene Editing and CRISPR-Cas9:
    • Gene editing, particularly through CRISPR-Cas9, is a major driver, relying on precise oligonucleotide synthesis.
    • Custom-designed oligonucleotides, such as guide RNAs (gRNAs), are crucial for targeting and modifying specific DNA sequences.
    • As gene editing expands in various fields, the market is poised for substantial growth.

Segmental Insights:

  1. Application Insights:
    • The Therapeutic Segment dominates the market, driven by the surge in RNA-based therapeutics and personalized medicine.
    • Custom-designed oligonucleotides are essential for gene editing, RNA interference, and precision medicine approaches.
    • Regulatory approvals and research collaborations further propel the therapeutic segment's expansion.
  2. Regional Insights:
    • North America leads the market, supported by a robust pharmaceutical and biotechnology industry, substantial investment in healthcare research, and a favorable regulatory environment.
    • The region's emphasis on precision medicine aligns with the demand for customized oligonucleotides.
    • Well-established infrastructure ensures efficient supply chains and timely delivery of oligonucleotides.

Key Market Players:

  1. Thermo Fisher Scientific Inc.
  2. Agilent Technologies, Inc.
  3. Merck KGaA
  4. BIO-Synthesis Inc.
  5. Eurofins Scientific SE
  6. Danaher Corporation
  7. Biogen Inc.
  8. Ionis Pharmaceuticals, Inc.
  9. Sarepta Therapeutics, Inc.

Report Scope

The report covers the Oligonucleotide Synthesis Market with detailed segmentation based on product type, application, end-user, and region. It provides comprehensive insights into industry trends, challenges, and key players, offering a thorough analysis of the market landscape.

This comprehensive report on the Global Oligonucleotide Synthesis Market provides a detailed understanding of its current state, key drivers, challenges, trends, and the competitive landscape. It covers crucial aspects such as market overview, key drivers, challenges, trends, key market players, and regional insights. Additionally, the report delves into segmental analysis, focusing on product type, application, end-user, and region. The competitive landscape section profiles key players, offering a detailed analysis of their business strategies, product offerings, and market presence.

Key Attributes

Report AttributeDetails
No. of Pages183
Forecast Period2022-2028
Estimated Market Value (USD) in 2022$4.03 Billion
Forecasted Market Value (USD) by 2028$8.52 Billion
Compound Annual Growth Rate13.3%
Regions CoveredGlobal

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Global Oligonucleotide Synthesis Market

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