Contact Information: Contact: Alyssa Nightingale 631-367-8599 anight@att.net
Cold Spring Harbor Laboratory Scientists Discover New Gene That Prevents Multiple Types of Cancer
| Source: Cold Spring Harbor Laboratory
COLD SPRING HARBOR, NY -- (MARKET WIRE) -- February 9, 2007 -- A decades-old cancer mystery has
been solved by researchers at Cold Spring Harbor Laboratory (CSHL). "We
not only found a critical tumor suppressor gene, but have revealed a master
switch for a tumor suppressive network that means more targeted and
effective cancer therapy in the future," said CSHL Associate Professor Alea
Mills, Ph.D. The study, headed by Mills, was published in the February
issue of Cell.
Specifically, Mills' discovery identifies CHD5, a protein that prevents
cancer, as a novel tumor suppressor, mapping to a specific portion of
chromosome 1 known as 1p36. When CHD5 is not functioning properly the
machinery within our cells that normally prevents cancer turns off. The
ability of CHD5 to function as a master switch for a tumor suppressive
network suggests that this gene is responsible for diverse forms of human
cancers.
After locating the region where the tumor suppressor resided, the Mills
team identified which genes in that area were responsible for tumor
suppression. Results showed that reducing expression of a single gene --
CHD5 -- made cells that had been rendered slow growing by adding an extra
copy of the region grow like normal cells.
The findings of Mills' study will influence the future of cancer research.
It shows that deletion of a part of 1p36 causes cancer and increased
"dosage" of CHD5 triggers extra tumor suppression. One extra dose, or copy,
caused cells to either stop dividing or to undergo cell suicide by
switching on a battery of potent tumor protective machinery. This work
indicates that pharmaceuticals that switch on CHD5 may provide a way to
treat many types of human cancer.
The research team worked with mouse models so they could investigate gains
and losses of the chromosome segment corresponding to human 1p36. To
extend the research to human cancer, Mills collaborated with Stanford
University researchers Dr. Hannes Vogel and Dr. Markus Bredel to study
whether CHD5 also functioned as a tumor suppressor in humans. They
discovered that glioma, a specific form of brain tumor, frequently had
deletion of CHD5, demonstrating the important role of CHD5 in human cancer.
This research and discovery was funded largely by private sector donations
which are important to support state-of-the-art research and discoveries
that may not traditionally be funded by the government. "The advance by
Dr. Mills and her team shows that CSHL's strategy of providing financial
resources to outstanding young scientists pays off towards diagnosing and
treating disease and human suffering," states CSHL President Bruce
Stillman.
The paper's citation is:
Bagchi A., Papazoglu C., Wu Y., Capurso D., Brodt M., Francis D., Bredel
M., Vogel H., Mills A.A. (2007) CHD5 is a tumor suppressor at human 1p36,
Cell 128, February 9, 2007.
CSHL is a private, non-profit research and education institution dedicated
to exploring molecular biology and genetics in order to advance the
understanding and ability to diagnose and treat cancers, neurological
diseases, and other causes of human suffering.