Las Vegas, USA, Oct. 20, 2021 (GLOBE NEWSWIRE) -- Exceptionally Robust Asthma Pipeline with More Than 100+ Pipeline Therapies Propelling the Lung Disease’s Research Sphere Extensively
Asthma is considered to be one of the world's most common diseases affecting the population and is also a life-threatening condition affecting patients' regular breathing. Asthma has a very robust research pipeline, with several candidates in the late and mid-stages of development. There are also several double and triple combination inhalers in late-stage development for asthma that aim to improve compliance rates.
DelveInsight’s ‘Asthma Pipeline Insight 2021’ report offers exhaustive global coverage of available, marketed, and pipeline therapies in different phases of clinical development, major pharmaceutical companies working to advance the pipeline space, and future growth potential of the Asthma pipeline domain.
Some of the essential takeaways from the Asthma Pipeline report:
- DelveInsight’s Asthma Pipeline analysis depicts a robust space with 100+ active players working to develop 100+ pipeline treatment therapies.
- Some of the key pharmaceutical companies working to develop potential drug candidates to improve the Asthma treatment scenario include Amgen, GlaxoSmithKline, Equillium, Viatris, Synermore Biologics, Tarus Therapeutics, Siolta Therapeutics, Chiesi Farmaceutici, Regeneron Pharmaceuticals, EURRUS Biotech, Palobiofarma SL, 4D pharma plc, AB Science, Pearl Therapeutics, Avillion, Novartis, Celltrion, AstraZeneca, Atopix Therapeutics, Glenmark Pharmaceuticals, EMS, Biohaven Pharmaceuticals, Inc., Teva Pharmaceutical, TFF Pharmaceuticals, Inc., Shanghai Hengrui Pharmaceutical Co., Ltd., Genentech, Inc., CSL Behring, Oneness Biotech Co., Ltd., Aldeyra Therapeutics, Inc., Shanghai Biomabs Pharmaceutical Co., Ltd., Suzhou Connect Biopharmaceuticals, Ltd., Kinaset Therapeutics Inc, Chia Tai Tianqing Pharmaceutical Group Co., Ltd, Evelo Biosciences, Inc, Atridia Pty Ltd., Keymed Biosciences Co.Ltd, and many others.
- Essential Asthma pipeline therapies such as Tezepelumab, Depemokimab, MG 01/T 517, Masitinib, BGF MDI, NOV-14, FB704A, TEV-53275, ADX-629, FP-025, SelK2, MRx-4DP0004, AQ001S, EQ001, SHR-1703, A2BR inhibitors, PR103, KN-002, TQC2731, Zavegepant, MTPS9579A, CM326, ZL-2102, Dexpramipexole, VR588, and others are under development in different phases of clinical trials.
- Tezepelumab is an investigational, potential first-in-class human monoclonal antibody that works on the primary source of inflammation: the airway epithelium, which is the first point of contact for viruses, allergens, pollutants and other environmental insults. The Food and Drug Administration (FDA) accepted Priority Review the Biologics License Application (BLA) for tezepelumab to treat patients suffering from severe asthma.
- GSK’294 is an investigational medicine with potential to be the first biologic to deliver long-acting suppression of IL-5 in patients with SEA from one subcutaneous injection every six months. GalaxoSmithKline has dosed a first patient in March 2021 to evaluate GSK 294 for the treatment of severe eosinophilic asthma (SEA).
- UK-based Vectura Group and Kinaset Therapeutics came under an agreement for the development and commercialization of VR588, an inhaled pan-JAK inhibitor for the treatment of severe asthma. The drug is currently being evaluated in Phase I clinical trials.
- In April 2020, LEO Pharma Enters License Agreement with Oneness Biotech and Microbio Shanghai for FB825 a Novel Atopic Dermatitis and Asthma Drug Candidate
- Aslan Pharma portfolio is led by ASLAN004, a novel, first-in-class antibody targeting the IL-13 receptor that has the potential to be the best-in-disease for atopic dermatitis and asthma.
- In September 2021, Albuterol/Budesonide Fixed-Dose Combo showed promising results in Phase III clinical trials.
- Masitinib, another potential Asthma pipeline therapy is under investigation for severe asthma which is uncontrolled by oral corticosteroids (OCS) and also in severe asthma uncontrolled by high dose inhaled corticosteroids (ICS). Positive Phase III results of masitinib in Severe Asthma uncontrolled by oral corticosteroids have been reported.
Request a sample and discover more about the report offerings @ Asthma Emerging Therapies
The Asthma pipeline report lays down detailed profiles of the pipeline assets, comparative analysis of clinical and non-clinical stage Asthma products, inactive and dormant assets, comprehensive assessment of driving and restraining factors, as well as the opportunities and risks in the Asthma pipeline landscape.
Asthma is a long-term condition affecting children and adults. The air passages in the lungs become narrow due to inflammation and tightening of the muscles around the small airways. This causes asthma symptoms: cough, wheeze, shortness of breath and chest tightness.
Asthma triggers vary from person to person but can include viral infections (colds), dust, smoke, fumes, changes in the weather, grass and tree pollen, animal fur and feathers, strong soaps, and perfume.
Find out more about the disease and recent developments @ Asthma Pipeline Assessment
Asthma Pipeline Drugs
| Drug | Company | Phase | MoA | RoA |
| Tezepelumab | Amgen | Preregistration | Thymic stromal lymphopoietin inhibitors | Intravenous |
| Depemokimab | GlaxoSmithKline | III | Interleukin 5 receptor antagonists | Subcutaneous |
| MG 01/T 517 | Inmunotek | III | Immunomodulators | Subcutaneous |
| Masitinib | AB Sciences | III | Colony stimulating factor inhibitors | Oral |
| BGF MDI | AstraZeneca | III | Beta 2 adrenergic receptor agonists | Inhalation |
| NOV-14 | Novartis | II | Thymic stromal lymphopoietin inhibitors | Inhalation |
| FB704A | Oneness Biotech | II | Interleukin 6 inhibitors | Intravenous |
| TEV-53275 | Teva Pharmaceutical | II | NA | Subcutaneous |
| ADX-629 | Aldeyra Therapeutics | II | Aldehyde inhibitors | Oral |
| FP-025 | Foresee Pharmaceuticals | II | Matrix metalloproteinase 12 inhibitors | Oral |
| SelK2 | Tetherex Pharmaceuticals | II | P-selectin ligand protein inhibitors | Intravenous |
| MRx-4DP0004 | 4D Pharma PLC | I/II | Bacteria replacements; Immunomodulators | Oral |
| AQ001S | Aquilon Pharma | I/II | NA | Inhalation |
| EQ001 | Equillium/ Biocon Limited | I | CD6 antigen inhibitors | Subcutaneous |
| SHR-1703 | Jiangsu Hengrui Medicine | I | Immunomodulators | Subcutaneous |
| A2BR inhibitors | Tarus Therapeutics | Preclinical | Adenosine A2B receptor antagonists | NA |
| PR103 | Shandong Boan Biotechnology | Preclinical | Interleukin 4 receptor antagonists | Parenteral |
Learn more about the novel and emerging Asthma pipeline therapies @ Asthma Pipeline Analysis
Asthma Therapeutics Assessment
The Asthma Pipeline report proffers an integral view of the Asthma emerging novel therapies segmented by Stage, Product Type, Molecule Type, Mechanism of Action and Route of Administration.
By Product Type
- Mono
- Combination
- Mono/Combination
By Stage
- Discovery
- Pre-clinical
- Phase I
- Phase II
- Phase III
- Pre-registration
- Inactive candidates
By Route of Administration
- Oral
- Parenteral
- Intravenous
- Subcutaneous
- Topical
- Inhalation
By Molecule Type
- Gene therapy
- Small molecules
- Monoclonal antibody
- Peptides
- Polymer
- Oligonucleotide
By Mechanism of Action
- Interleukin 4 receptor antagonists
- Adenosine A2B receptor antagonists
- Interleukin 6 inhibitors
- Aldehyde inhibitor
- Thymic stromal lymphopoietin inhibitor
- Colony-stimulating factor inhibitors
- Immunomodulator
- Interleukin 5 receptor antagonists
Scope of the Asthma Pipeline Report
- Coverage: Global
- Major Players: Amgen, GlaxoSmithKline, Equillium, Viatris, Synermore Biologics, Tarus Therapeutics, Siolta Therapeutics, Chiesi Farmaceutici, Regeneron Pharmaceuticals, EURRUS Biotech, Palobiofarma SL, 4D pharma plc, AB Science, Pearl Therapeutics, Avillion, Novartis, Celltrion, AstraZeneca, Atopix Therapeutics, Glenmark Pharmaceuticals, EMS, Biohaven Pharmaceuticals, Inc., Teva Pharmaceutical, TFF Pharmaceuticals, Inc., Shanghai Hengrui Pharmaceutical Co., Ltd., Genentech, Inc., CSL Behring, Oneness Biotech Co., Ltd., Aldeyra Therapeutics, Inc., Shanghai Biomabs Pharmaceutical Co., Ltd., Suzhou Connect Biopharmaceuticals, Ltd., Kinaset Therapeutics Inc, Chia Tai Tianqing Pharmaceutical Group Co., Ltd, Evelo Biosciences, Inc, Atridia Pty Ltd., Keymed Biosciences Co.Ltd, and others.
- Key Asthma Pipeline Therapies: Tezepelumab, Depemokimab, MG 01/T 517, Masitinib, BGF MDI, NOV-14, FB704A, TEV-53275, ADX-629, FP-025, SelK2, MRx-4DP0004, AQ001S, EQ001, SHR-1703, A2BR inhibitors, PR103, KN-002, TQC2731, Zavegepant, MTPS9579A, CM326, ZL-2102, Dexpramipexole, VR588, and others.
Dive deep into rich insights for emerging therapies and assessment, visit @ Asthma Emerging Therapies
Table of Contents
| 1 | Introduction |
| 2 | Executive Summary |
| 3 | Asthma: Overview |
| 4 | Pipeline Therapeutics |
| 5 | Therapeutic Assessment |
| 6 | Asthma – DelveInsight’s Analytical Perspective |
| 7 | Late Stage Products (Pre-registration) |
| 7.1 | Tezepelumab: Amgen |
| 8 | Mid Stage Products (Phase II) |
| 8.1 | NOV-14: Novartis |
| 9 | Early Stage Products (Phase I) |
| 9.1 | SHR-1703: Jiangsu Hengrui Medicine |
| 10 | Preclinical and Discovery Stage Products |
| 10.1 | Research programme: A2BR inhibitors: Tarus Therapeutics |
| 11 | Inactive Products |
| 12 | Asthma Key Companies |
| 13 | Asthma Key Products |
| 14 | Asthma- Unmet Needs |
| 15 | Asthma- Market Drivers and Barriers |
| 16 | Asthma- Future Perspectives and Conclusion |
| 17 | Asthma Analyst Views |
| 18 | Asthma Key Companies |
| 19 | Appendix |
| 20 | About DelveInsight |
For further information on the Asthma current pipeline therapeutics, reach out @ Asthma Ongoing Clinical Trials
Track and assess a candidate’s clinical development journey through Actionable Intelligence and Comparative Therapeutic Assessment
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