New York, USA, April 19, 2023 (GLOBE NEWSWIRE) -- Mesothelioma Clinical Trials Pipeline Analysis: 50+ Companies are Working to Improve the Treatment Space | DelveInsight
The prevalence of mesothelioma has been rising over the past few years, which prompts the growing demand for treatment options. The increasing prevalence of mesothelioma and the growing research and development activities to develop novel therapies to treat mesothelioma to drive the market. The companies developing the potential therapies in the last stage of development include AstraZeneca, Amphera, Sumitomo Pharma Oncology, and several others.
DelveInsight’s 'Mesothelioma Pipeline Insight 2023' report provides comprehensive global coverage of available, marketed, and pipeline mesothelioma therapies in various stages of clinical development, major pharmaceutical companies are working to advance the pipeline space and future growth potential of the mesothelioma pipeline domain.
Key Takeaways from the Mesothelioma Pipeline Report
- DelveInsight’s mesothelioma pipeline report depicts a robust space with 50+ active players working to develop 55+ pipeline therapies for mesothelioma treatment.
- Key mesothelioma companies such as Amphera BV, Momotaro-Gene Inc., Novartis Pharmaceuticals, Oncovir, Inc., Sumitomo Pharma Oncology, Bayer, Trizell Ltd, Hutchison Medipharma Limited, Targovax, Polaris Group, Sanofi, Ascentage Pharma Group Inc., GlaxoSmithKline, Constellation Pharmaceuticals, Xencor, Inc., NGM Biopharmaceuticals, Inc, Inhibrx, Inc., VM Oncology, LLC, SOTIO Biotech AG, Atara Biotherapeutics, Targovax ASA, Oncotelic Therapeutics, Epizyme, Inc., AstraZeneca, RS Oncology LLC, Vivace Therapeutics, Inc, ImmVira Pharma Co. Ltd, Shionogi Inc., Compass Therapeutics, CRISPR Therapeutics, TCR2 Therapeutics, Mirati Therapeutics Inc., Seagen Inc., Ikena Oncology, Xencor, Inc., Aminex Therapeutics, Inc., ProfoundBio, Verismo Therapeutics, and others are evaluating new mesothelioma drugs to improve the treatment landscape.
- Promising mesothelioma pipeline therapies such as MesoPher, MTG201, IAG933, Poly-ICLC, BBI608, Anetumab ravtansine, rAd-IFN, CPI-0209, XmAb20717, HMPL-453, INBRX-109, SO-C101, VMD-928, NGM707, ONCOS-102, iCasp9M28z, ADI-PEG 20, SAR444245, APG-5918, Niraparib, OT-101, Tazemetostat, RSO-021, VT3989, APG-2449, T3011, S-488210, CTX-471, CTX131, TC-510, MRTX1719, SGN-BB228, IK-930, XmAb20717, AMXT1501, PRO1184, SynKIR 110, and others are under different phases of mesothelioma clinical trials.
- In April 2023, Verismo Therapeutics, a clinical-stage CAR T company, Penn spinout, and pioneer of the novel KIR-CAR platform technology, announced that it has received Fast Track designation from the U.S. Food and Drug Administration (FDA) for its investigational new drug, SynKIR-110, for the treatment of patients with mesothelioma. SynKIR-110 is an investigational new drug for the treatment of mesothelin-expressing mesothelioma, cholangiocarcinoma and ovarian cancer.
- In March 2023, Merck and the Canadian Cancer Trials Group (CCTG) reported positive data from the Phase II/III CCTG IND.227/KEYNOTE-483 trial of Keytruda, along with chemotherapy, as first-line treatment for advanced malignant pleural mesothelioma patients. According to the final study analysis, the combination of Keytruda and chemotherapy met the trial’s primary endpoint of overall survival (OS), demonstrating a clinically meaningful and statistically significant improvement in OS compared to chemotherapy alone.
- In March 2023, Avenge Bio, Inc. announced that it completed a pre-Investigational New Drug (IND) meeting with the U.S. Food and Drug Administration ("FDA") with respect to AVB-001 for the treatment of malignant pleural mesothelioma, and provided a corporate update. Preliminary feedback was received from the FDA on the future development of AVB-001 for the treatment of malignant pleural mesothelioma. Avenge obtained guidance from the FDA on its preclinical and clinical development plans and remains on track to submit an IND in the second half of 2023.
- In January 2023, Ultimovacs ASA announced the completed recruitment of 118 patients with pleural mesothelioma in the NIPU trial. NIPU is a randomized, multicenter phase II trial initiated and sponsored by Oslo University Hospital with support from Bristol-Myers Squibb and Ultimovacs. UV1 is being evaluated in combination with the checkpoint inhibitors ipilimumab and nivolumab as second-line treatment for patients with malignant pleural mesothelioma.
- In September 2022, TCR2 Therapeutics Inc. announced positive topline results from the Phase I portion of the gavo-cel Phase I/II clinical trial for mesothelin-expressing solid tumors, with some patients still being monitored for clinical response or stable disease. The patients were heavily pretreated with a median of five prior lines of therapy, including immune checkpoint inhibitors in 66% of patients and mesothelin-directed therapies in 19% of patients.
Request a sample and discover the recent advances in mesothelioma treatment drugs @ Mesothelioma Pipeline Report
The mesothelioma pipeline report provides detailed profiles of pipeline assets, a comparative analysis of clinical and non-clinical stage mesothelioma drugs, inactive and dormant assets, a comprehensive assessment of driving and restraining factors, and an assessment of opportunities and risks in the mesothelioma clinical trial landscape.
Mesothelioma Overview
Mesothelioma is an asbestos-related cancer. It usually develops in the lining of the lungs or the abdomen. The average life expectancy after diagnosis is 18 to 31 months, but the prognosis may improve with treatment. Chest pain, shortness of breath, and general fatigue are all possible mesothelioma symptoms. Any level of asbestos exposure can cause mesothelioma. Certain occupations, however, may have higher rates of exposure. Based on the location of the tumor, there are four main types of mesothelioma. Malignant pleural mesothelioma is the most common. After recognizing mesothelioma symptoms, doctors will conduct a battery of tests and procedures to confirm a mesothelioma diagnosis. Biopsies are the only way to definitively diagnose mesothelioma. Surgery, chemotherapy, and radiation therapy are the most common mesothelioma treatments. The most common approach is a multimodal approach, which combines two or more standard mesothelioma treatment options.
Find out more about mesothelioma treatment drugs @ Drugs for Mesothelioma Treatment
A snapshot of the Mesothelioma Pipeline Drugs mentioned in the report:
| Drugs | Company | Phase | MoA | RoA |
| Durvalumab | AstraZeneca | Phase III | Programmed cell death-1 ligand-1 inhibitors; T lymphocyte stimulants | Intravenous |
| MesoPher | Amphera | Phase II/III | Immunostimulants | Intravenous |
| REIC gene therapy | Momotaro-Gene Inc. | Phase II | Apoptosis stimulants; DKK3 expression modulators; Gene transference; Tumour suppressor gene modulators | Intratumoral |
| Napabucasin | Sumitomo Pharma Oncology | Phase I/II | Beta catenin inhibitors; Cell death stimulants; STAT3 transcription factor inhibitors; Stem cell inhibitors | Oral |
| Tulmimetostat | MorphoSys | Phase I/II | Enhancer of zeste homolog 2 protein inhibitors | Oral |
| IAG933 | Novartis Pharmaceuticals | Phase I | Undefined mechanism | Oral |
| VT3989 | Vivace Therapeutics, Inc. | Phase I | Transcription factor inhibitors | Oral |
Learn more about the emerging Mesothelioma pipeline therapies @ Mesothelioma Clinical Trials
Mesothelioma Therapeutics Assessment
The mesothelioma pipeline report proffers an integral view of the mesothelioma emerging novel therapies segmented by stage, product type, molecule type, mechanism of action, and route of administration.
Scope of the Mesothelioma Pipeline Report
- Coverage: Global
- Mesothelioma Therapeutic Assessment By Product Type: Mono, Combination, Mono/Combination
- Mesothelioma Therapeutic Assessment By Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III
- Mesothelioma Therapeutics Assessment By Route of Administration: Oral, Parenteral, Intravenous, Subcutaneous, Topical
- Mesothelioma Therapeutics Assessment By Molecule Type: Monoclonal Antibody, Peptides, Polymer, Small molecule, Gene therapy
- Mesothelioma Therapeutics Assessment By Mechanism of Action: Immunostimulants, Programmed cell death-1 ligand-1 inhibitors, T lymphocyte stimulants, Apoptosis stimulants, DKK3 expression modulators, Gene transference, Tumour suppressor gene modulators, Dipeptidyl peptidase 4 inhibitors, Beta catenin inhibitors, Cell death stimulants, STAT3 transcription factor inhibitors, Stem cell inhibitors, Enhancer of zeste homolog 2 protein inhibitors
- Key Mesothelioma Companies: Amphera BV, Momotaro-Gene Inc., Novartis Pharmaceuticals, Oncovir, Inc., Sumitomo Pharma Oncology, Bayer, Trizell Ltd, Hutchison Medipharma Limited, Targovax, Polaris Group, Sanofi, Ascentage Pharma Group Inc., GlaxoSmithKline, Constellation Pharmaceuticals, Xencor, Inc., NGM Biopharmaceuticals, Inc, Inhibrx, Inc., VM Oncology, LLC, SOTIO Biotech AG, Atara Biotherapeutics, Targovax ASA, Oncotelic Therapeutics, Epizyme, Inc., AstraZeneca, RS Oncology LLC, Vivace Therapeutics, Inc, ImmVira Pharma Co. Ltd, Shionogi Inc., Compass Therapeutics, CRISPR Therapeutics, TCR2 Therapeutics, Mirati Therapeutics Inc., Seagen Inc., Ikena Oncology, Xencor, Inc., Aminex Therapeutics, Inc., ProfoundBio, Verismo Therapeutics, and others
- Key Mesothelioma Pipeline Therapies: MesoPher, MTG201, IAG933, Poly-ICLC, BBI608, Anetumab ravtansine, rAd-IFN, CPI-0209, XmAb20717, HMPL-453, INBRX-109, SO-C101, VMD-928, NGM707, ONCOS-102, iCasp9M28z, ADI-PEG 20, SAR444245, APG-5918, Niraparib, OT-101, Tazemetostat, RSO-021, VT3989, APG-2449, T3011, S-488210, CTX-471, CTX131, TC-510, MRTX1719, SGN-BB228, IK-930, XmAb20717, AMXT1501, PRO1184, SynKIR 110, and others
Dive deep into rich insights for new drugs for Mesothelioma treatment, visit @ Mesothelioma Drugs
Table of Contents
| 1. | Mesothelioma Pipeline Report Introduction |
| 2. | Mesothelioma Pipeline Report Executive Summary |
| 3. | Mesothelioma Pipeline: Overview |
| 4. | Analytical Perspective In-depth Commercial Assessment |
| 5. | Mesothelioma Clinical Trial Therapeutics |
| 6. | Mesothelioma Pipeline: Late Stage Products (Pre-registration) |
| 7. | Mesothelioma Pipeline: Late Stage Products (Phase III) |
| 7.1. | Durvalumab: AstraZeneca |
| 8. | Mesothelioma Pipeline: Mid Stage Products (Phase II) |
| 8.1. | REIC gene therapy: Momotaro-Gene Inc. |
| 9. | Mesothelioma Pipeline: Early Stage Products (Phase I) |
| 9.1. | IAG933: Novartis Pharmaceuticals |
| 10. | Mesothelioma Pipeline Therapeutics Assessment |
| 11. | Inactive Products in the Mesothelioma Pipeline |
| 12. | Company-University Collaborations (Licensing/Partnering) Analysis |
| 13. | Key Companies |
| 14. | Key Products in the Mesothelioma Pipeline |
| 15. | Unmet Needs |
| 16. | Market Drivers and Barriers |
| 17. | Future Perspectives and Conclusion |
| 18. | Analyst Views |
| 19. | Appendix |
For further information on the mesothelioma pipeline therapeutics, reach out @ Mesothelioma Treatment Drugs
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