Glycotope and Max Delbrück Center enter into research collaboration to explore combination of GlycoTargets and CAR technology
Berlin, Germany, 25 September 2023 – Glycotope GmbH (Glycotope) and the Max Delbrück Center for Molecular Medicine in the Helmholtz Association have signed an agreement to explore the potential of combining Glycotope’s antibodies against protein/carbohydrate combined glyco-epitopes (GlycoTargets) with chimeric antigen receptor (CAR) technology developed by the Max Delbrück Center.
CARs are engineered synthetic receptors that function to redirect lymphocytes, most commonly T-cells, to recognise and eliminate cells expressing a specific target antigen. These cell-based therapies have demonstrated exciting results in clinical trials and are rapidly becoming powerful alternatives to conventional treatments for hematologic cancers in particular. However, in some indications, including harder to treat cancers with solid tumors, success has been limited. A major problem facing drug developers is the selection of suitable antigens that are only expressed on tumors, and can therefore be targeted safely. In the scope of the newly established collaboration, highly tumor-specific antibodies developed by Glycotope will be combined with the CAR technology of the Max Delbrück Center to analyze their suitability for the treatment of solid tumors.
“CAR-T cells have dramatically improved the treatment of hematologic malignancies. In stark contrast, CAR-T cells lack efficacy against solid tumors, which by far outnumber incidence and mortality rates of leukemia and lymphoma. Epidemiologically, breast, lung, prostate, and colon cancers are the most common "killers" which cannot be successfully targeted using current T cell therapies,” said Dr Armin Rehm, who heads the Translational Tumorimmunology Lab at the Max Delbrück Center. "But antibodies can recognize tumor-associated aberrant glycosylation, making it an attractive and tumor-specific target structure. This feature, together with a broad tumor-specific expression, paves the way for the generation of glycan-redirected CAR-T and NK cells. Thus, we are joining forces for a new generation of CAR-T and NK cells," said Dr Höpken, Head of the Lab Environmental Regulation in Autoimmunity and Cancer at the Max Delbrück Center, and Dr Rehm.
“We are pleased to have gained another renowned collaboration partner and look forward to working with the experienced scientists from Uta's and Armin's groups to evaluate how our targeting approach can help advance cellular therapies for solid tumors,” added Dr Patrik Kehler, CSO at Glycotope.
Glycotope’s antibodies target specific tumor-associated carbohydrate structures or protein/carbohydrate combined glyco-epitopes (GlycoTargets). Targeting these specific antigens enables broad indication range, long-term treatment potential and reduced on-target/off tumor toxicity, key elements of highly potent therapies. Based on this unrivalled tumor-specificity, Glycotope’s antibodies are highly suitable for a multi-function platform approach with independent modes of action to provide a tailored therapy format for as many patients as possible.
The CAR program at the Max Delbrück Center includes several proprietary antibody binders targeting hematologic tumors. This program involves the development of a full preclinical validation, a clinical scale automated manufacturing platform, and the initiation of two phase I/II clinical trials in collaboration with clinical partners. A comprehensive molecular toolbox of modular CAR components enables rapid integration of new antibody binders. Extensive experience in CAR design, retroviral engineering for CAR transfer, regulatory advice by authorities, and established methodologies to generate T cell and NK cell effector populations for in vitro and in vivo testing will facilitate the implementation of innovative antibodies in our next-generation CAR platform, targeting tumor-associated glycan structures.
Contact Information:
Glycotope GmbH
Dr Patrik Kehler (CSO)
Phone: +49 30 9489 2600
Email: contact@glycotope.com
Max Delbrück Center for Molecular Medicine in the Helmholtz Association
Dr Armin Rehm, Head of the Translational Tumorimmunology Lab
Phone: +49 30 9460 3817
Email: arehm@mdc-berlin.de
Max Delbrück Center for Molecular Medicine in the Helmholtz Association
Dr Uta Höpken, Head of the Microenvironmental Regulation in Autoimmunity and Cancer Lab
Phone: +49 30 9460 3330
Email: uhoepken@mdc-berlin.de
Media Contacts:
Chris Gardner, Chris Welsh
ICR Consilium
Phone: +44 20 3709 5700
Email: glycotope@consillium-comms.com
Jana Schlütter
Communications Department, Max Delbrück Center
Phone: +49 (0) 30 9406 2121
Email: jana.schluetter@mdc-berlin.de or presse@mdc-berlin.de
About Glycotope
Glycotope is a biotechnology company utilizing a proprietary technology platform to develop uniquely tumor-specific monoclonal antibodies. Our antibodies target specific tumor-associated carbohydrate structures or protein/carbohydrate combined glyco-epitopes (GlycoTargets). Glycotope has to date discovered in excess of 200 GlycoTargets with antibodies against several of these targets currently under development.
Based on their superior tumor-specificity, our antibodies are suitable for development in an array of different modes of action including naked antibodies, bispecifics, antibody-drug-conjugates, cellular therapies or fusion-proteins. Visit www.glycotope.com
About the Max Delbrück Center
The Max Delbrück Center for Molecular Medicine in the Helmholtz Association (Max Delbrück Center) is one of the world’s leading biomedical research institutions. Max Delbrück, a Berlin native, was a Nobel laureate and one of the founders of molecular biology. At the locations in Berlin-Buch and Mitte, researchers from some 70 countries study human biology – investigating the foundations of life from its most elementary building blocks to systems-wide mechanisms. By understanding what regulates or disrupts the dynamic equilibrium of a cell, an organ, or the entire body, we can prevent diseases, diagnose them earlier, and stop their progression with tailored therapies. Patients should benefit as soon as possible from basic research discoveries. The Max Delbrück Center therefore supports spin-off creation and participates in collaborative networks. It works in close partnership with Charité – Universitätsmedizin Berlin in the jointly run Experimental and Clinical Research Center (ECRC), the Berlin Institute of Health (BIH) at Charité, and the German Center for Cardiovascular Research (DZHK). Founded in 1992, the Max Delbrück Center today employs 1,800 people and is funded 90 percent by the German federal government and 10 percent by the State of Berlin. Visit www.mdc-berlin.de
