Dublin, April 15, 2024 (GLOBE NEWSWIRE) -- The "Sezary Syndrome - Pipeline Insights, 2024" has been added to ResearchAndMarkets.com's offering.
The report provides comprehensive insights about 5+ companies and 5+ pipeline drugs in Sezary syndrome pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
The report provides comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Sezary syndrome pipeline landscape is provided which includes the disease overview and Sezary syndrome treatment guidelines. The assessment part of the report embraces, in depth Sezary syndrome commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Sezary syndrome collaborations, licensing, mergers and acquisition, funding, designations and other product related details.
Sezary syndrome Emerging Drugs Chapters
This segment of the Sezary syndrome report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
Sezary syndrome Emerging Drugs
Lacutamab: Innate PharmaLacutamab (IPH4102) is a first-in-class anti-KIR3DL2 humanized cytotoxicity-inducing antibody, which is currently in clinical trials for treatment of cutaneous T-cell lymphoma (CTCL), an orphan disease. This group of rare cutaneous lymphomas of T lymphocytes has a poor prognosis with few efficacious and safe therapeutic options at advanced stages. KIR3DL2 is an inhibitory receptor of the KIR family, expressed by approximately 65% of patients across all CTCL subtypes and expressed by up to 90% of patients with certain aggressive CTCL subtypes, in particular, Sezary syndrome. It is expressed by up to 50% of patients with peripheral T-cell lymphoma (PTCL). It has a restricted expression on normal tissues. n November 2020, Innate Pharma announced that the European Medicines Agency (EMA) has granted PRIME designation to lacutamab, the Company's proprietary first-in-class anti-KIR3DL2 humanized cytotoxicity-inducing antibody, for the treatment of patients with relapsed or refractory Sezary syndrome (SS) who have received at least two prior systemic therapies. It is currently in phase II stage of development and is being developed by Innate Pharma.
Resminostat: 4SCResminostat is an orally administered histone deacetylase (HDAC) inhibitor that potentially represents a novel therapy for a broad spectrum of oncology indications, both in monotherapy and particularly in combination with other anti-cancer drugs. In preclinical models, resminostat has shown selectivity for class I, IIB and IV HDAC enzymes with a particular specificity toward inhibiting the protein HDAC6, which is active in metastasis. Resminostat has the potential to provide significant benefit to patients by inhibiting tumor progression and metastasis, inducing tumor regression and enhancing the body's own immune response to cancer. It is currently in phase II stage of development and is being developed by 4SC for Sezary syndrome.
Major Players in Sezary syndrome
There are approx. 5+ key companies which are developing the therapies for Sezary syndrome. The companies which have their Sezary syndrome drug candidates in the most advanced stage, i.e. Phase II include, Innate Pharma.
Phases
This report covers around 5+ products under different phases of clinical development like
- Late stage products (Phase III)
- Mid-stage products (Phase II)
- Early-stage product (Phase I) along with the details of
- Pre-clinical and Discovery stage candidates
- Discontinued & Inactive candidates
Route of Administration
Sezary syndrome pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as
- Oral
- Parenteral
- Intravenous
- Subcutaneous
- Topical.
Molecule Type
Products have been categorized under various Molecule types such as
- Monoclonal Antibody
- Peptides
- Polymer
- Small molecule
- Gene therapy
Product Type
- Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.
Sezary syndrome : Pipeline Development Activities
- The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Sezary syndrome therapeutic drugs key players involved in developing key drugs.
Pipeline Development Activities
- The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Sezary syndrome drugs.
Sezary syndrome Report Insights
- Sezary syndrome Pipeline Analysis
- Therapeutic Assessment
- Unmet Needs
- Impact of Drugs
Sezary syndrome Report Assessment
- Pipeline Product Profiles
- Therapeutic Assessment
- Pipeline Assessment
- Inactive drugs assessment
- Unmet Needs
Key Questions
Current Treatment Scenario and Emerging Therapies:
- How many companies are developing Sezary syndrome drugs?
- How many Sezary syndrome drugs are developed by each company?
- How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Sezary syndrome?
- What are the key collaborations (Industry-Industry, Industry-Academia), Mergers and acquisitions, licensing activities related to the Sezary syndrome therapeutics?
- What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
- What are the clinical studies going on for Sezary syndrome and their status?
- What are the key designations that have been granted to the emerging drugs?
Company Coverage:
- 4SC AG
- Seagen Inc.
- Merck Sharp & Dohme Corp.
- Innate Pharma
- Trillium Therapeutics
- Secura Bio
For more information about this clinical trials report visit https://www.researchandmarkets.com/r/6ct0yj
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