Phase Ia data on TMC435350 to be presented at AASLD

Phase Ia data on TMC435350 to be presented at AASLD

Medivir announced that their abstracts for the 58th Annual Meeting of the
American Association for Study of Liver Diseases (AASLD) have been published
today and are available on Hepatology web site (AASLD).

The two abstracts summarize the results from a phase I clinical trial and
further preclinical data that will be presented by Medivir and Tibotec, on their
investigational compound TMC435350, a hepatitis C protease inhibitor, at AASLD
in Boston, Massachusetts, USA on November 6th, 2007. The two posters are titled
“Results of a phase I placebo-controlled trial in healthy volunteers to examine
safety, tolerability and PK of the protease inhibitor TMC435350 after single and
repeated dosing” and “In vitro activity and preclinical PK of a potent HCV
NS3/4A serine protease inhibitor, TMC435350”. 

Data from the phase Ia clinical trial show that TMC435350 was well tolerated in
single doses up to 600 mg and in 5 days of dosing up to 400 mg once-daily. 

The project has advanced to phase Ib trials, where its ability to suppress virus
in patients infected with Hepatitis C is being investigated following once-daily
oral dosing. 

“The successful outcome of the phase Ia clinical trial is the single most
important milestone for Medivir so far this year” comments Lars Adlersson, CEO &
President at Medivir. 

Chronic infection with the hepatitis C virus (HCV) leads to liver diseases.
According to the WHO, 3% of the global population is infected with HCV, which
means 200 million individuals. In the USA, 1.8% of the population is infected,
that is 3.9 million people. In more than 60% of these cases, the HCV infection
leads to chronic liver disease, cirrhosis and liver tumors. It is the most
common reason for liver transplant. The HCV market is currently dominated by
interferon-based treatments.


For additional information, please contact
Rein Piir, CFO & Vice President Investor Relations, Medivir AB, +46 708 537292

For more information on Medivir, please see the company website www.medivir.se