Not for release, publication or distribution in Australia, Canada, Japan or the United States This announcement does not constitute an offer to sell or the solicitation of an offer to buy the securities of NeuroSearch A/S (the “Securities”) in Australia, Canada, Japan or the United States or in any other jurisdiction. Securities may not be offered or sold in the United States absent registration or an exemption from registration under the U.S. Securities Act of 1933, as amended. The issuer of the Securities has not registered, and does not intend to register, any portion of the Offering in the United States, and does not intend to conduct a public offering of the Securities in the United States. Notice to UK residents This announcement is only being distributed to, and is only directed at, persons in the United Kingdom that are qualified investors as that term is defined in the Prospectus Directive that are also (i) “investment professionals” falling within article 19(5) of the Financial Service and Markets Act 2000 (Financial Promotion) Order 2005 (the “Order”) or (ii)“high net worth entities” and other persons to whom it may lawfully be communicated, falling within the meaning of Article 49(2)(a) to (d) of the Order (all such persons being “relevant persons”). The offered shares of NeuroSearch A/S are only available to relevant persons and any invitation, offer or agreement to subscribe, purchase or otherwise acquire such offered shares will be engaged in only with relevant persons. Any person who is not a relevant person should not act or rely on this document or any of its content. -------------------------------------------------------------------------- Pursuant to section 28a of the Danish Act on Securities Trading, NeuroSearch A/S (NEUR.CO) shall make public transactions with shares and related securities of NeuroSearch A/S by persons discharging managerial responsibilities and persons/companies closely associated with these. Name: Thomas Hofman-Bang Reason: Chairman of the Board Issuer: NeuroSearch A/S ISIN code: DK0060192771 Transaction: Subscription of shares Trade date: 27 October 2009 Market: NASDAQ OMX Copenhagen A/S Number (pcs): 1,328 Market value (DKK): 79,680 Name: Mads P. G. Korsgaard Reason: Member of the Board Issuer: NeuroSearch A/S ISIN code: DK0060192771 Transaction: Subscription of shares Trade date: 27 October 2009 Market: NASDAQ OMX Copenhagen A/S Number (pcs): 129 Market value (DKK): 7,740 Name: Flemming Pedersen Reason: CEO Issuer: NeuroSearch A/S ISIN code: DK0060192771 Transaction: Subscription of shares Trade date: 27 October 2009 Market: NASDAQ OMX Copenhagen A/S Number (pcs): 1,807 Market value (DKK): 108,420 Name: Naapster ApS Reason: A company owned by Flemming Pedersen, CEO of NeuroSearch A/S Issuer: NeuroSearch A/S ISIN code: DK0060192771 Transaction: Subscription of shares Trade date: 27 October 2009 Market: NASDAQ OMX Copenhagen A/S Number (pcs): 472 Market value (DKK): 28,320 Name: Nicholas Waters Reason: CEO of NeuroSearch Sweden AB Issuer: NeuroSearch A/S ISIN code: DK0060192698 Transaction: Sale of preemptive rights Trade date: 23 October 2009 Market: NASDAQ OMX Copenhagen A/S Number (pcs): 30,000 Market value (DKK): 144,300 Name: Nicholas Waters Reason: CEO of NeuroSearch Sweden AB Issuer: NeuroSearch A/S ISIN code: DK0060192698 Transaction: Sale of preemptive rights Trade date: 26 October 2009 Market: NASDAQ OMX Copenhagen A/S Number (pcs): 5 Market value (DKK): 23 Name: Nicholas Waters Reason: CEO of NeuroSearch Sweden AB Issuer: NeuroSearch A/S ISIN code: DK0060192771 Transaction: Subscription of shares Trade date: 27 October 2009 Market: NASDAQ OMX Copenhagen A/S Number (pcs): 4,285 Market value (DKK): 257,100 Name: Susanna Waters Reason: Related to Nicholas Waters, CEO of NeuroSearch Sweden AB Issuer: NeuroSearch A/S ISIN code: DK0060192698 Transaction: Sale of preemptive rights Trade date: 23 October 2009 Market: NASDAQ OMX Copenhagen A/S Number (pcs): 16,827 Market value (DKK): 80,938 Name: Susanna Waters Reason: Related to Nicholas Waters, CEO of NeuroSearch Sweden AB Issuer: NeuroSearch A/S ISIN code: DK0060192698 Transaction: Sale of preemptive rights Trade date: 26 October 2009 Market: NASDAQ OMX Copenhagen A/S Number (pcs): 6 Market value (DKK): 28 Name: Susanna Waters Reason: Related to Nicholas Waters, CEO of NeuroSearch Sweden AB Issuer: NeuroSearch A/S ISIN code: DK0060192771 Transaction: Subscription of shares Trade date: 27 October 2009 Market: NASDAQ OMX Copenhagen A/S Number (pcs): 2,404 Market value (DKK): 144,240 Name: Frank Wätjen Reason: Member of the Executive Management Issuer: NeuroSearch A/S ISIN code: DK0060192698 Transaction: Sale of preemptive rights Trade date: 23 October 2009 Market: NASDAQ OMX Copenhagen A/S Number (pcs): 3,500 Market value (DKK): 17,850 Name: Frank Wätjen Reason: Member of the Executive Management Issuer: NeuroSearch A/S ISIN code: DK0060192698 Transaction: Sale of preemptive rights Trade date: 26 October 2009 Market: NASDAQ OMX Copenhagen A/S Number (pcs): 34,977 Market value (DKK): 161,349 Name: Frank Wätjen Reason: Member of the Executive Management Issuer: NeuroSearch A/S ISIN code: DK0060192771 Transaction: Subscription of shares Trade date: 27 October 2009 Market: NASDAQ OMX Copenhagen A/S Number (pcs): 3,100 Market value (DKK): 186,000 Name: Jørgen Drejer Reason: Member of the Executive Management Issuer: NeuroSearch A/S ISIN code: DK0060192698 Transaction: Sale of preemptive rights Trade date: 23 October 2009 Market: NASDAQ OMX Copenhagen A/S Number (pcs): 10,701 Market value (DKK): 51,365 Name: Jørgen Drejer Reason: Member of the Executive Management Issuer: NeuroSearch A/S ISIN code: DK0060192698 Transaction: Sale of preemptive rights Trade date: 26 October 2009 Market: NASDAQ OMX Copenhagen A/S Number (pcs): 23,919 Market value (DKK): 115,201 Name: Jørgen Drejer Reason: Member of the Executive Management Issuer: NeuroSearch A/S ISIN code: DK0060192771 Transaction: Subscription of shares Trade date: 27 October 2009 Market: NASDAQ OMX Copenhagen A/S Number (pcs): 12,000 Market value (DKK): 720,000 Name: Jørgen Drejer Reason: Member of the Executive Management Issuer: NeuroSearch A/S ISIN code: DK0010224666 Transaction: Sale of shares Trade date: 27 October 2009 Market: NASDAQ OMX Copenhagen A/S Number (pcs): 6,100 Market value (DKK): 549,000 Name: Jørgen Drejer Reason: Member of the Executive Management Issuer: NeuroSearch A/S ISIN code: DK0010224666 Transaction: Subscription of shares Trade date: 27 October 2009 Market: NASDAQ OMX Copenhagen A/S Number (pcs): 6,100 Market value (DKK): 549,000 Name: Anita Milland Reason: Member of the VP Group Issuer: NeuroSearch A/S ISIN code: DK0060192771 Transaction: Subscription of shares Trade date: 27 October 2009 Market: NASDAQ OMX Copenhagen A/S Number (pcs): 151 Market value (DKK): 9,060 Contact person: Anita Milland, Vice President, CFO, telephone +45 4460 8274 or +45 2016 3432 About NeuroSearch NeuroSearch (NEUR) is a Scandinavian biopharmaceutical company listed on NASDAQ OMX Copenhagen A/S. The core business of the company covers the development of novel pharmaceutical agents, based on a broad and well-established drug discovery platform focusing on ion channels and central nervous system (CNS) disorders. A substantial share of the activities is partner financed through strategic alliances with Janssen Pharmaceutica, Eli Lilly and Company and GlaxoSmithKline (GSK), and a license collaboration with Abbott. The drug pipeline comprises eight clinical (Phase I-III) development programmes: Huntexil™ (pridopidine) for Huntington's disease (Phase III), tesofensine for obesity (Phase III ready), ABT-894 for ADHD (Phase II) in partnership with Abbott, ACR343 for schizophrenia (Phase II ready), ACR325 to treat dyskinesias in Parkinson's disease (Phase Ib), ABT-560 for the treatment of cognitive dysfunctions (Phase I) in collaboration with Abbott, NSD-788 for anxiety (Phase I) and NSD-721 for social anxiety disorder (Phase I) in partnership with GSK. In addition, NeuroSearch has a broad portfolio of preclinical drug candidates and holds equity interests in several biotech companies.
Report of transactions with shares and related securities of NeuroSearch by persons discharging managerial responsibilities and person/companies closely associated with these
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