Major Shareholder Announcement


Topotarget A/S
Symbion
Fruebjergvej 3
DK 2100 Copenhagen
Denmark
Tel: +45 39 17 83 92
Fax: +45 39 17 94 92
CVR-nr: 25695771
www.topotarget.com


Copenhagen - 19 April, 2010 - Topotarget A/S (NASDAQ OMX: TOPO) hereby
announces that the Company has today received a notification from BankInvest,
that BankInvest's holdings of shares and voting rights are now less than 5% of
Topotarget's total share capital and total number of voting rights. 

Today's news does not change Topotarget's full-year financial guidance.

Topotarget A/S


For further information, please contact:

Francois Martelet	Direct		+45 39 17 94 99
CEO		Mobil		+45 31 36 83 41


Background information

About Topotarget 
Topotarget (NASDAQ OMX: TOPO) is an international biotech company headquartered
in Denmark, dedicated to finding ''Answers for Cancer'' and developing improved
cancer therapies. Topotarget currently focuses, in collaboration with Spectrum
Pharmaceuticals, Inc., on the development in pivotal studies of its lead drug
candidate, Belinostat, which has shown proof of concept as monotherapy in
treating haematological malignancies and positive results in solid tumours.
Belinostat can be used in combination with full doses of chemotherapy, and is
in a pivotal trial within PTCL (peripheral T-cell lymphoma). Topotarget is
directing its efforts on belinostat and on additional key cancer targets,
including HDACi, NAD+, mTOR, FASLigand and topoisomerase II inhibitors. The
Company's first marketed product, Savene®/Totect®, was approved by EMEA in 2006
and the FDA in 2007, and is marketed by Topotarget's own sales force in the US.
For more information, please refer to www.topotarget.com. 

Topotarget Safe Harbour Statement
This announcement may contain forward-looking statements, including statements
about our expectations of the progression of our preclinical and clinical
pipeline including the timing for commencement and completion of clinical
trials and with respect to cash burn guidance. Such statements are based on
management's current expectations and are subject to a number of risks and
uncertainties that could cause actual results to differ materially from those
described in the forward-looking statements. Topotarget cautions investors that
there can be no assurance that actual results or business conditions will not
differ materially from those projected or suggested in such forward-looking
statements as a result of various factors, including, but not limited to, the
following: The risk that any one or more of the drug development programs of
Topotarget will not proceed as planned for technical, scientific or commercial
reasons or due to patient enrolment issues or based on new information from
non-clinical or clinical studies or from other sources; the success of
competing products and technologies; technological uncertainty and product
development risks;  uncertainty of additional funding; Topotarget's history of
incurring losses and the uncertainty of achieving profitability; Topotarget's
stage of development as a biopharmaceutical company; government regulation;
patent infringement claims against Topotarget's products, processes and
technologies; the ability to protect Topotarget's patents and proprietary
rights; uncertainties relating to commercialization rights; and product
liability expo-sure; We disclaim any intention or obligation to update or
revise any forward-looking statements, whether as a result of new information,
future events, or otherwise, unless required by law.

Attachments

announcement no 14-10 major share announcement.pdf