Director/PDMR Shareholding

Transaction by Person Discharging Managerial Responsibilities

Disclosure Rule DTR 3.1.4

On 1 August 2014, Bruce Burlington, a Director of the Company notified us that,
on 1 August 2014, he purchased 500 AstraZeneca American Depositary Shares (ADSs)
at a price of $72.71 per ADS.

One AstraZeneca ADS equals one AstraZeneca PLC Ordinary Share of $0.25.

A C N Kemp

Company Secretary

4 August 2014