Director/PDMR Shareholding

Transaction by Person Discharging Managerial Responsibilities

Disclosure Rule DTR 3.1.4

On 25 February 2016, the interest of Mr Pascal Soriot, a person discharging
managerial responsibilities, in the ordinary shares of AstraZeneca PLC changed
as detailed below.

The change in interest relates to the previously announced award of shares made
in February 2013 under the AstraZeneca Deferred Bonus Plan. Under the terms of
the award, Mr Soriot has now become beneficially entitled to the shares.
After sufficient shares were withheld to satisfy certain tax obligations arising
on the vesting, Mr Soriot has become beneficially entitled to and has received
3,039 shares into a personal brokerage account.
For tax purposes, the fair market value of the shares at vest was 4086.5 pence
per share being the closing price of AstraZeneca ordinary shares on the last
trading day preceding the vesting day.

A C N Kemp
Company Secretary
26 February 2016