Summit Therapeutics plc : Holding(s) in Company


TR-1: NOTIFICATION OF MAJOR INTEREST IN SHARESⁱ

1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached: ⁱⁱ		Summit Therapeutics Plc
2 Reason for the notification (please tick the appropriate box or boxes):
An acquisition or disposal of voting rights
An acquisition or disposal of qualifying financial instruments which may result in the acquisition of shares already issued to which voting rights are attached			X
An acquisition or disposal of instruments with similar economic effect to qualifying financial instruments
An event changing the breakdown of voting rights
Other (please specify):
3. Full name of person(s) subject to the notification obligation: ⁱⁱⁱ	Point72 Asset Management, L.P. Point72 Capital Advisors Inc. Steven A. Cohen
4. Full name of shareholder(s) (if different from 3.):^iv	N/A (holding consists entirely of ADRs)
5. Date of the transaction and date on which the threshold is crossed or reached: ^v	7 April 2016
6. Date on which issuer notified:	8 April 2016
7. Threshold(s) that is/are crossed or reached: ^{vi, vii}	7%

8. Notified details:

A: Voting rights attached to shares ^{viii, ix}

Class/type of
shares

if possible using
the ISIN CODE

Situation previous
to the triggering
transaction

Resulting situation after the triggering transaction

Number
of
Shares

Number
of
Voting
Rights

Number
of shares

Number of voting
rights

% of voting rights ^x

Direct

Direct ^xi

Indirect ^xii

Direct

Indirect

B: Qualifying Financial Instruments

Resulting situation after the triggering transaction

Type of financial
instrument

Expiration
date ^xiii

Exercise/
Conversion Period ^xiv

Number of voting
rights that may be
acquired if the
instrument is
exercised/ converted.

% of voting
rights

ADRs
US86627R1023

N/A

4,879,240

7.96%

C: Financial Instruments with similar economic effect to Qualifying Financial Instruments ^{xv, xvi}

Resulting situation after the triggering transaction

Type of financial
instrument

Exercise price

Expiration date ^xvii

Exercise/
Conversion period ^xviii

Number of voting rights instrument refers to

% of voting rights ^{xix, xx}

Nominal

Delta

Total (A+B+C)

Number of voting rights

Percentage of voting rights

4,879,240

7.96%

9. Chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held, if applicable: ^xxi
Point72 Asset Management L.P. is the investment manager of certain funds that hold the financial instruments disclosed in Section 8 of this form and which controls the voting rights attached to those financial instruments. Point72 Capital Advisors Inc. is the general partner of Point72 Asset Management L.P. Steven A. Cohen is a parent undertaking of Point72 Capital Advisors Inc.

Proxy Voting:
10. Name of the proxy holder:
11. Number of voting rights proxy holder will cease to hold:
12. Date on which proxy holder will cease to hold voting rights:

13. Additional information:
14. Contact name:	Raquel U. Trout
15. Contact telephone number:	+1 203-890-3862