Disclosure under Chapter 9, Section 5 of the Finnish Securities Markets Act


BIOTIE THERAPIES CORP.             STOCK EXCHANGE RELEASE       12 April, 2016 at 11.20 p.m.

Disclosure under Chapter 9, Section 5 of the Finnish Securities Markets Act

Biotie Therapies Corp. (Nasdaq Helsinki BTH1V; NASDAQ: BITI) ("Biotie" or the "Company") has on April 12, 2016 received a notification in accordance with Chapter 9, Section 5 of the Finnish Securities Markets Act ("SMA") from Mr. Samuel D. Isaly on behalf of himself and OrbiMed Advisors LLC, OrbiMed Capital GP V LLC and OrbiMed Private Investments V, LP.

According to the notification, the total number of Biotie shares owned directly or through financial instruments by Samuel D. Isaly and entities under his control has fallen below the threshold of 5 per cent on April 11, 2016. Biotie's registered total number of shares and voting rights amounting to 1,089,608,083 has been used in the calculation of percentages for the announcement.

Total positions of Samuel D. Isaly and entities under his control subject to the notification:

  % of shares and voting rights (total of A) % of shares and voting rights through financial instruments (total of B) Total of both in % (A + B)
Resulting situation on the date on which threshold was crossed or reached Below 5 % Below 5 % Below 5 %
Position of previous notification (if applicable) 6.76 4.78 11.54

Notified details of the resulting situation on the date on which the threshold was crossed or reached:

A: Shares and voting rights

Class/type of shares
ISIN code (if possible)
Number of shares and voting rights % of shares and voting rights
Direct
(SMA 9:5)
Indirect
(SMA 9:6 and 9:7)
Direct
(SMA 9:5)
Indirect
(SMA 9:6 and 9:7)
Shares
(FI0009011571)
- - - -
American Depositary Shares (ADS), each representing 80 Shares
(FI0009011571)
- - - -
SUBTOTAL A   Below 5 %

B: Financial instruments according to SMA 9:6a

Type of financial instrument Expiration date Exercise/
Conversion period
Physical or cash settlement Number of shares and voting rights % of shares and voting rights
Warrants entitling to subscribe for Shares (FI0009011571) Nov 1, 2020 Nov 1, 2015 - Nov 1, 2020 Physical settlement - -
      SUBTOTAL B   Below 5 %

Full chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held starting with the ultimate controlling natural person or legal entity:

Name % of shares and voting rights % of shares and voting rights through financial instruments Total of both
Samuel D. Isaly Below 5 % Below 5 % Below 5 %
OrbiMed Advisors LLC Below 5 % Below 5 % Below 5 %
OrbiMed Capital GP V LLC Below 5 % Below 5 % Below 5 %
OrbiMed Private Investments V, LP Below 5 % Below 5 % Below 5 %

According to the notification, Samuel D. Isaly is the managing member of and owner of a controlling interest in OrbiMed Advisors LLC, which is the sole managing member of OrbiMed Capital GP V LLC. OrbiMed Capital GP V LLC is the general partner of OrbiMed Private Investments V, LP. Further, according to the notification neither Samuel D. Isaly nor any other entity under his control holds shares or financial instruments in the Company exceeding a notification threshold.

In Turku, April 12, 2016

Biotie Therapies Corp.

Timo Veromaa
President and CEO

For further information, please contact:

Virve Nurmi, Investor Relations Manager, Biotie Therapies Corp.
tel. +358 2 274 8900, e-mail: virve.nurmi@biotie.com

DISTRIBUTION:

Nasdaq Helsinki Ltd
Main Media
www.biotie.com

HUG#2003005