Redding, California, April 14, 2021 (GLOBE NEWSWIRE) -- According to a new market research report titled “Continuous Bioprocessing Market by Product (Filtration, Chromatography, Centrifuges, Consumables), Application (Commercial {Vaccines, Monoclonal Antibodies}, R&D), End User (Pharmaceuticals, Biotechnology, CROs), and Geography - Forecast to 2027”, published by Meticulous Research®, the continuous bioprocessing market is expected to grow at a CAGR of 22.9% from 2020 to 2027 to reach $197.8 million by 2027.
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Continuous bioprocessing consists of integrated continuous unit processes without intermediate holding tanks through which product travels into containers in a constant flow. Continuous unit operations are characterized by extremely intensified processing with short downtimes. An end-to-end bioprocess includes perfusion bioreactors, multi-column chromatography systems, and multi-column intermediate purification systems. Some pharma and biopharma manufacturers are adopting a hybrid approach to continuous bioprocessing in which only upstream or downstream process is operated continuously.
The growth in the continuous bioprocessing market is mainly attributed to the growing demand for biopharmaceuticals, growing development of new technologies and products related to continuous bioprocessing, and rising government support for biopharmaceutical manufacturing. In addition, significant opportunities in Asia-Pacific and Latin America and growing approval for personalized medicines further support this market's growth. However, factors such as the high risk of contamination with continuous bioprocessing, the complex nature of continuous bioprocessing in downstream processes, and the shortage of bioprocessing professionals are expected to hinder the adoption of continuous bioprocessing.
Over the years, several advances have been made in bioprocessing to cut costs, improve product yield, and streamline integration between upstream and downstream processing. Advances in upstream processing have focused on key areas like increased volumetric productivity through process intensification, increasing cell-specific productivity, greater cellular and molecular biology, and accelerating process development timeline. Bioprocessing operations have also led to other innovations like continuous improvements in cell expression systems and development and improvement of disposable bioreactors impacting bioprocessing operations, leading to new product launches. For instance, in September 2020, Cytiva (U.S.) launched its Xcellerex Automated Perfusion System (APS) for biotherapeutic manufacturing.
Impact of COVID-19 on the Continuous Bioprocessing Market
The global COVID-19 pandemic has affected the healthcare industry diversely. The adoption of continuous bioprocessing technologies is expected to rise due to accelerated R&D to manufacture COVID-19 vaccines.
To curb the spread of the novel COVID-19 virus, countries worldwide went under strict lockdowns, which resulted in the disrupted supply chains for sourcing raw materials. With the growing vaccine and therapeutic candidates in the pipeline, the demand for novel manufacturing approaches like continuous processing is accelerating, positively impacting the market.
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The biopharma industry is focusing on adopting flexible and adaptable approaches, necessitating the adoption of flexible manufacturing strategies like continuous bioprocessing. This adaptability helps the industry develop and produce COVID-19 vaccines, diagnostics, equipment, and therapeutics. Attention has focused on the development of vaccines, new antiviral agents, and convalescent plasma infusions. For instance, monoclonal antibodies, a type of therapeutic agent, are under investigation to treat COVID-19. In November 2020, the FDA granted emergency use authorization for both bamlanivimab and the combination of casirivimab and imdevimab in outpatients with mild to moderate COVID-19 who are at high risk for severe COVID-19. The companies like GlaxoSmithKline Plc. (U.K.), Sanofi (France), Johnson & Johnson (U.S.) are exploring different approaches like recombinant protein therapy and viral vector platforms for discovering COVID-19 vaccine modalities.
The continuous bioprocessing market is segmented on the basis of product (filtration, chromatography, centrifuges, consumables), application (commercial {vaccines, monoclonal antibodies}, R&D), end user (pharmaceuticals, biotechnology, CROs), and geography. The study also evaluates industry competitors and analyzes their market share at the global and regional levels.
Based on product, the filtration systems and consumables segment accounted for the largest share of the overall continuous bioprocessing market in 2020. The growing demand for higher standards of filter operations in biopharma manufacturing is one of the major drivers for this segment's growth. Filter manufacturers are developing filtration technologies for continuous bioprocessing to achieve both separation and purification through a combination of physical removal capabilities of filtration and size exclusion.
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On the basis of application, the commercial segment accounted for the largest share of the overall continuous bioprocessing market in 2020. Growing investments in constructing facilities compatible with continuous bioprocessing for biopharmaceuticals' commercial manufacturing is a key market driver. Also, the growing approval of antibodies and therapeutic proteins and on-going and future capacity expansions by various commercial biopharmaceutical manufacturers to cater to unmet demand for vaccines and other biopharmaceutical products in a short period is accelerating the growth of this segment. Commercial manufacturing includes vaccine manufacturing, mAb manufacturing, gene and cell therapy manufacturing, and recombinant protein production. In 2020, the mAb manufacturing segment accounted for the largest share of the market.
Based on end user, CDMOs and CROs segment is projected to grow at the highest CAGR over the forecast period due to the growing trend towards outsourcing biologics manufacturing and favorable regulatory reforms for CMOs.
Some of the key players operating in the global continuous bioprocessing market are 3M (U.S.), Cytiva (U.S.), Thermo Fisher Scientific, Inc. (U.S.), Merck KGaA (Germany), Sartorius AG (Germany), Repligen Corporation (U.S.), Eppendorf AG (Germany), Applikon Biotechnology (The Netherlands), Pall Corporation (U.S.), and Bionet (Spain) among others.
To gain more insights into the market with a detailed table of content and figures, click here: https://www.meticulousresearch.com/product/continuous-bioprocessing-market-5079
Scope of the Report:
Continuous Bioprocessing Market, by Product
- Filtration Systems and Consumables
- Chromatography Systems and Consumables
- Bioreactors
- Sterilizers
- Centrifuges
- Incubators and Shakers
- Mixing Systems
- Cell Culture Media, Buffers, and Reagents
- Other Instruments and Consumables
Continuous Bioprocessing Market, by Application
- Commercial
- Vaccines
- mAb Production
- Recombinant Protein Production
- Cell and Gene Therapy Production
- R&D
Continuous Bioprocessing Market, by End User
- Pharmaceutical and Biotechnology Companies
- Contract Development and Manufacturing Organizations and Contract Research Organizations
- Academic and Research Institutes
Continuous Bioprocessing Market, by Geography
- North America
- U.S.
- Canada
- Europe
- Germany
- U.K.
- France
- Italy
- Spain
- Rest of Europe (RoE)
- Asia-Pacific (APAC)
- China
- Japan
- India
- Rest of APAC (RoAPAC)
- Latin America
- Middle East & Africa
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