Las Vegas, USA, Oct. 04, 2021 (GLOBE NEWSWIRE) -- Epilepsy Pipeline: Insights into Novel and Emerging Pipeline Therapies, Key Pharma Players, Clinical Trials, Growth Prospects, and Treatment Landscape | DelveInsight
The Epilepsy Pipeline landscape is evolving with increased insight into biological pathways and mechanisms underlying Epilepsy, leading towards more targeted therapies.
DelveInsight’s ‘Epilepsy Pipeline Insight 2021’ report offers exhaustive global coverage of available, marketed, and pipeline therapies under different phases of clinical development, key companies working to advance the pipeline space, and future growth potential of the Epilepsy pipeline domain.
Some of the essential takeaways from the Epilepsy Pipeline report:
- DelveInsight’s Epilepsy Pipeline analysis depicts the space with 70+ active players working to develop 70+ pipeline therapies.
- Major pharmaceutical companies are developing potential drug candidates to improve the Epilepsy treatment scenario, such as Otsuka Pharmaceutical Co. Ltd, Cerebral Therapeutics LLC, Marinus Pharmaceuticals, Xenon Pharmaceuticals, PTC Therapeutics, Eisai, Longboard Pharmaceuticals, Neurocrine Biosciences, and others.
- Key Epilepsy pipeline therapies such as OPC-214870, CT-010, Ganaxolone, XEN496, Vatiquinone E-2730, LP352, NBI 827104, and others are under investigation in different phases of clinical trials.
- In January 2021, Addex Therapeutics announced that its partner Janssen Pharmaceuticals had received FDA’s Investigational New Drug (IND) approval to begin a Phase IIa proof of concept study with the selective metabotropic glutamate type 2 (mGlu2) receptor positive allosteric modulator (PAM), JNJ-40411813 (ADX71149), in patients with Epilepsy.
- In October 2020, PTC Therapeutics announced the initiation of a registration-directed Phase II/III clinical trial to evaluate vatiquinone (PTC743) in patients with mitochondrial Epilepsy, the highly morbid condition of refractory seizures in children with inherited mitochondrial disease.
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The Epilepsy pipeline report lays down detailed profiles of the pipeline assets, inactive and dormant assets, comparative analysis of clinical and non-clinical stage Epilepsy products, comprehensive assessment of driving and restraining factors, and opportunities as well as risks in the Epilepsy pipeline landscape.
Epilepsy Overview
Epilepsy is a chronic neurological disorder characterized by frequent and recurring seizures leading to unusual behavior. The primary cause of Epilepsy is not clear, but it is noted that any change in the nerve cells, neurons, and the brain resulting in abnormal signals can be the possible reason.
The most common symptom of Epilepsy includes seizures; however, additional symptoms like convulsion without fever, low consciousness, less awareness, loss of taste, smell, sight, hearing, etc., can also be present.
For further information about Epilepsy treatment and pipeline therapies, visit @ Epilepsy Pipeline Assessment
Epilepsy Pipeline Drugs
| Drug | Company | Phase | MoA | RoA |
| OPC-214870 | Otsuka Pharmaceutical Co. Ltd | Phase I | Antiepileptic | Oral |
| CT-010 | Cerebral Therapeutics LLC | Phase II | 4-aminobutyrate transaminase inhibitors | Intraventricular |
| Ganaxolone | Marinus Pharmaceuticals | Phase III | GABA A receptor agonists | Intravenous |
| XEN496 | Xenon Pharmaceuticals | Phase III | KCNQ potassium channel agonists | Oral |
| Vatiquinone | PTC Therapeutics | Phase II/III | NQO1 modulators | Oral |
| E-2730 | Eisai | Phase II | Synaptic transmission modulators | Oral |
| NBI 827104 | Neurocrine Biosciences | Phase II | T type calcium channel antagonists | Oral |
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Epilepsy Therapeutics Assessment
The Epilepsy Pipeline report proffers an integral view of the Epilepsy emerging novel therapies segregated by Stage, Product Type, Route of Administration, Molecule Type, and Mechanism of Action.
By Product Type
- Mono
- Combination
- Mono/Combination
By Stage
- Discovery
- Pre-clinical
- Phase I
- Phase II
- Phase III
- Pre-registration
By Route of Administration
- Subcutaneous
- Intravenous
- Oral
- Intraventricular
- Inhalation
By Molecule Type
- Gene therapy
- Stem cell therapy
- Small molecules
- Pyridines
By Mechanism of Action
- 4-aminobutyrate transaminase inhibitors
- GABA A receptor agonists
- KCNQ potassium channel agonists
- NQO1 modulators
- Serotonin receptor agonists
- T type calcium channel antagonists
By Targets
- GABA A receptor
- KCNQ potassium channel
- Serotonin receptor
- NQO1
- T type calcium channel
- Synaptic transmission
Scope of the Epilepsy Pipeline Report
- Coverage: Global
- Major Players: Otsuka Pharmaceutical Co. Ltd, Cerebral Therapeutics LLC, Marinus Pharmaceuticals, Xenon Pharmaceuticals, PTC Therapeutics, Eisai, Longboard Pharmaceuticals, Neurocrine Biosciences, and others.
- Key Epilepsy Pipeline Therapies: OPC-214870, CT-010, Ganaxolone, XEN496, Vatiquinone E-2730, LP352, NBI 827104, and others.
Dive deep into rich insights of Epilepsy novel and emerging drugs and their analysis @ Epilepsy Pipeline Emerging Novel Therapies
Table of Contents
| 1 | Introduction |
| 2 | Executive Summary |
| 3 | Epilepsy: Overview |
| 4 | Epilepsy - Analytical Perspective In-depth Commercial Assessment |
| 5 | Pipeline Therapeutics |
| 6 | Late Stage Products (Phase III) |
| 7 | Late Stage Products (Phase II/III) |
| 8 | Mid Stage Products (Phase II) |
| 9 | Early Stage Products (Phase I) |
| 10 | Therapeutic Assessment |
| 11 | Inactive Products |
| 12 | Company-University Collaborations (Licensing/Partnering) Analysis |
| 13 | Epilepsy Key Companies |
| 14 | Epilepsy Key Products |
| 15 | Epilepsy- Unmet Needs |
| 16 | Epilepsy- Market Drivers and Barriers |
| 17 | Epilepsy- Future Perspectives and Conclusion |
| 18 | Epilepsy Analyst Views |
| 19 | Appendix |
| 20 | About DelveInsight |
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- In the United States, more than 2.5 million people are living with Epilepsy, out of which approximately 1 million continue to experience seizures despite adequate treatment with antiseizure drugs.
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- The term Epilepsy isn’t new. It’s been present in the air for centuries now, however, only a few are aware that it is one of the most common neurological diseases in the world.
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