Las Vegas, USA, Oct. 12, 2021 (GLOBE NEWSWIRE) -- DelveInsight Evaluates a Robust Pipeline for Myelodysplastic Syndrome as Influential Pharma Players Set Foot in the MDS Landscape
Myelodysplastic Syndrome (MDS) pipeline landscape is going to boost in coming years owing to promising late-stage pipeline candidates and the entry of novel agents as new therapies.
DelveInsight’s ‘Myelodysplastic Syndrome Pipeline Insight 2021’ report offers exhaustive global coverage of available, marketed, and pipeline therapies in different phases of clinical development, key companies working to advance the pipeline space, and future growth potential of the Myelodysplastic Syndrome pipeline domain.
Some of the salient features of the Myelodysplastic Syndrome Pipeline report:
- DelveInsight’s Myelodysplastic Syndrome Pipeline analysis presents the MDS domain with 100+ active players in the domain investigating 100+ pipeline therapies.
- Many key companies are developing potential drug candidates to improve the ongoing Myelodysplastic Syndrome treatment, such as Horizon Pharma USA, Gilead Sciences, Astex Pharmaceuticals, Syntrix Biosystems, Syros Pharmaceuticals, Aprea Therapeutics, Celgene Corporation, Salarius Pharmaceuticals, Novartis Pharmaceuticals, and others.
- Emerging Myelodysplastic Syndrome pipeline therapies such as IFN-γ (interferon gamma-1b) injection, Magrolimab, ASTX030, SX-682, Tamibarotene, APR-246, Luspatercept, Seclidemstat, MBG453, and others are under investigation in different phases of clinical trials.
- In September 2021, Jasper Therapeutics announced the initiation of a Phase I/II clinical trial to evaluate JSP191 as a targeted, non-toxic conditioning agent prior to allogeneic transplant in patients with GATA2-related Myelodysplastic Syndrome (MDS). Jasper Therapeutics and the National Cancer Institute (NCI), part of the National Institutes of Health, had entered into a clinical trial agreement in which NCI will serve as the Investigational New Drug (IND) sponsor for this study.
- In July 2021, Roche announced that Venclexta (venetoclax) in combination with azacitidine had been granted Breakthrough Therapy Designation (BTD) by the US FDA for the treatment of adult patients with previously untreated intermediate, high- and very high-risk Myelodysplastic Syndrome (MDS) based on the revised International Prognostic Scoring System (IPSS-R).
- In August 2020, Keros Therapeutics initiated a study to develop a candidate for treating low blood cell counts or cytopenias. It includes anaemia and thrombocytopenia in patients with Myelodysplastic Syndrome (MDS) and Myelofibrosis (MF).
Request for Sample to know which MDS pipeline therapy is anticipated to be at the front in the coming years @ Myelodysplastic Syndrome Pipeline Therapeutics Assessment
The Myelodysplastic Syndrome pipeline report offers detailed profiles of the pipeline assets and the inactive and dormant assets, comparative analysis of clinical and non-clinical stage Myelodysplastic Syndrome products, comprehensive assessment of driving and restraining factors along with the opportunities and risks in the MDS pipeline landscape.
Myelodysplastic Syndrome Overview
Myelodysplastic Syndrome is a group of cancers in which immature blood cells in the bone marrow do not mature, so they do not become healthy blood cells. Myelodysplastic Syndrome is divided into subtypes based on blood cells — red cells, white cells, and platelets.
Myelodysplastic Syndrome rarely causes signs or symptoms in the early stages. In time, MDS might cause fatigue, shortness of breath, unusual paleness due to a low red blood cell count (anaemia), unusual bruising or bleeding due to a low blood platelet count (thrombocytopenia).
Myelodysplastic Syndrome Pipeline Drugs
| Drug | Company | Phase | MoA | RoA |
| Magrolimab | Gilead Sciences | Phase III | CD47 antigen inhibitors | Intravenous |
| ASTX030 | Astex Pharmaceuticals | Phase II/III | Cytidine deaminase inhibitors | Oral |
| SX-682 | Syntrix Biosystems | Phase I/II | Interleukin 8 receptor antagonists | Oral |
| Tamibarotene | Syros Pharmaceuticals | Phase III | Retinoic acid receptor alpha agonists | Oral |
| APR-246 | Aprea Therapeutics | Phase III | Thioredoxin reductase inhibitors | Intravenous |
| Seclidemstat | Salarius Pharmaceuticals | Phase I/II | Lysine specific demethylase 1 inhibitors | Oral |
| MBG453 | Novartis Pharmaceuticals | Phase III | HAVCR2 protein inhibitors | Intravenous |
Explore more about Myelodysplastic Syndrome novel pipeline therapeutic landscape @ Myelodysplastic Syndrome Pipeline Novel and Emerging Drugs
Myelodysplastic Syndrome Therapeutics Assessment
The Myelodysplastic Syndrome Pipeline report proffers an integral view of the Myelodysplastic syndrome emerging novel therapies segmented by Stage, Product Type, Route of Administration, Molecule Type, Target, and Mechanism of Action.
By Product Type
- Mono
- Combination
By Stage
- Discovery
- Pre-clinical
- Phase I
- Phase II
- Phase III
- Pre-registration
By Route of Administration
- Subcutaneous
- Intravenous
- Oral
By Molecule Type
- Peptides
- Monoclonal Antibodies
- Small molecules
- Polysaccharides
- Immunotherapies
By Mechanism of Action
- CD47 antigen inhibitors
- Cytidine deaminase inhibitors
- Interleukin 8 receptor antagonists
- Retinoic acid receptor alpha agonists
- Thioredoxin reductase inhibitors
- HAVCR2 protein inhibitors
By Targets
- CD47 antigen
- Interleukin 8 receptor
- Cytidine deaminase
- Thioredoxin reductase
- HAVCR2 protein
Scope of the Myelodysplastic Syndrome Pipeline Report
- Coverage: Global
- Major Players: Horizon Pharma USA, Gilead Sciences, Astex Pharmaceuticals, Syntrix Biosystems, Syros Pharmaceuticals, Aprea Therapeutics, Celgene Corporation, Salarius Pharmaceuticals, Novartis Pharmaceuticals, and others.
- Key Myelodysplastic Syndrome Pipeline Theraṣpies: IFN-γ (interferon gamma-1b) injection, Magrolimab, ASTX030, SX-682, Tamibarotene, APR-246, Luspatercept, Seclidemstat, MBG453, and others.
Get a customized MDS pipeline report @ Myelodysplastic Syndrome Pipeline and Future Prospects
Table of Contents
| 1 | Introduction |
| 2 | Executive Summary |
| 3 | Myelodysplastic Syndrome: Overview |
| 4 | Myelodysplastic Syndrome: Analytical Perspective In-depth Commercial Assessment |
| 5 | Pipeline Therapeutics |
| 6 | Late Stage Products (Phase III) |
| 7 | Mid Stage Products (Phase II) |
| 8 | Early Stage Products (Phase I) |
| 9 | Early Phase I |
| 10 | Therapeutic Assessment |
| 11 | Inactive Products |
| 12 | Company-University Collaborations (Licensing/Partnering) Analysis |
| 13 | Myelodysplastic Syndrome Key Companies |
| 14 | Myelodysplastic Syndrome Key Products |
| 15 | Myelodysplastic Syndrome - Unmet Needs |
| 16 | Myelodysplastic Syndrome - Market Drivers and Barriers |
| 17 | Myelodysplastic Syndrome - Future Perspectives and Conclusion |
| 18 | Myelodysplastic Syndrome Analyst Views |
| 19 | Appendix |
Explore more about the scope of the report @ Myelodysplastic Syndrome Treatment & Clinical Trials
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